FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086041829> ?p ?o ?g. }

• W2086041829 endingPage "8501" @default.
• W2086041829 startingPage "8489" @default.
• W2086041829 abstract "Responses resulting from injury to the trigeminal nerve exhibit differences compared with those caused by lesion of other peripheral nerves. With the aim of elucidating the physiopathological mechanisms underlying cephalic versus extracephalic neuropathic pain, we determined the time course expression of proinflammatory cytokines interleukin-6 (IL-6) and IL-1β, neuronal injury (ATF3), macrophage/microglial (OX-42), and satellite cells/astrocyte (GFAP) markers in central and ganglion tissues in rats that underwent unilateral chronic constriction injury (CCI) to either infraorbital nerve (IoN) (cephalic area) or sciatic nerve (SN) (extracephalic area). Whereas CCI induced microglial activation in both models, we observed a concomitant upregulation of IL-6 and ATF3 in the ipsilateral dorsal horn of the lumbar cord in SN-CCI rats but not in the ipsilateral spinal nucleus of the trigeminal nerve (Sp5c) in IoN-CCI rats. Preemptive treatment with minocycline (daily administration of 20 mg/kg, i.p., for 2 weeks) partially prevented pain behavior and microglial activation in SN-CCI rats but was ineffective in IoN-CCI rats. We show that IL-6 can upregulate OX-42 and ATF3 expression in cultured microglia and neurons from spinal cord, respectively, as well as in the dorsal horn after acute intrathecal administration of the cytokine. We propose that IL-6 could be one of the promoters of the signaling cascade leading to abnormal pain behavior in SN-CCI but not IoN-CCI rats. Our data further support the idea that different pathophysiological mechanisms contribute to the development of cephalic versus extracephalic neuropathic pain." @default.
• W2086041829 created "2016-06-24" @default.
• W2086041829 creator A5001240923 @default.
• W2086041829 creator A5008454281 @default.
• W2086041829 creator A5019098800 @default.
• W2086041829 creator A5020397435 @default.
• W2086041829 creator A5038507730 @default.
• W2086041829 creator A5047849578 @default.
• W2086041829 creator A5066380904 @default.
• W2086041829 date "2008-08-20" @default.
• W2086041829 modified "2023-10-16" @default.
• W2086041829 title "Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats" @default.
• W2086041829 cites W1646647792 @default.
• W2086041829 cites W1853688909 @default.
• W2086041829 cites W1966820993 @default.
• W2086041829 cites W1967588398 @default.
• W2086041829 cites W1969668074 @default.
• W2086041829 cites W1973993040 @default.
• W2086041829 cites W1974093633 @default.
• W2086041829 cites W1974300877 @default.
• W2086041829 cites W1976219259 @default.
• W2086041829 cites W1978678518 @default.
• W2086041829 cites W1979859079 @default.
• W2086041829 cites W1997404777 @default.
• W2086041829 cites W2000535898 @default.
• W2086041829 cites W2009230499 @default.
• W2086041829 cites W2013271691 @default.
• W2086041829 cites W2014182104 @default.
• W2086041829 cites W2016448869 @default.
• W2086041829 cites W2018877420 @default.
• W2086041829 cites W2023771303 @default.
• W2086041829 cites W2025421728 @default.
• W2086041829 cites W2029439578 @default.
• W2086041829 cites W2033728392 @default.
• W2086041829 cites W2040088974 @default.
• W2086041829 cites W2040768738 @default.
• W2086041829 cites W2046212133 @default.
• W2086041829 cites W2048131048 @default.
• W2086041829 cites W2052193782 @default.
• W2086041829 cites W2054519722 @default.
• W2086041829 cites W2055952684 @default.
• W2086041829 cites W2058020736 @default.
• W2086041829 cites W2063451203 @default.
• W2086041829 cites W2070512478 @default.
• W2086041829 cites W2077885131 @default.
• W2086041829 cites W2077926137 @default.
• W2086041829 cites W2078039934 @default.
• W2086041829 cites W2079688458 @default.
• W2086041829 cites W2081901209 @default.
• W2086041829 cites W2090305787 @default.
• W2086041829 cites W2098296304 @default.
• W2086041829 cites W2098605131 @default.
• W2086041829 cites W2107277218 @default.
• W2086041829 cites W2116903459 @default.
• W2086041829 cites W2120955132 @default.
• W2086041829 cites W2136817451 @default.
• W2086041829 cites W2139698257 @default.
• W2086041829 cites W2145221987 @default.
• W2086041829 cites W2146109161 @default.
• W2086041829 cites W2158230836 @default.
• W2086041829 cites W2159746265 @default.
• W2086041829 cites W2162730620 @default.
• W2086041829 cites W2164116575 @default.
• W2086041829 cites W2165190391 @default.
• W2086041829 cites W2171476133 @default.
• W2086041829 cites W2888001539 @default.
• W2086041829 cites W4313152550 @default.
• W2086041829 doi "https://doi.org/10.1523/jneurosci.2552-08.2008" @default.
• W2086041829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6671060" @default.
• W2086041829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18716207" @default.
• W2086041829 hasPublicationYear "2008" @default.
• W2086041829 type Work @default.
• W2086041829 sameAs 2086041829 @default.
• W2086041829 citedByCount "99" @default.
• W2086041829 countsByYear W20860418292012 @default.
• W2086041829 countsByYear W20860418292013 @default.
• W2086041829 countsByYear W20860418292014 @default.
• W2086041829 countsByYear W20860418292015 @default.
• W2086041829 countsByYear W20860418292016 @default.
• W2086041829 countsByYear W20860418292017 @default.
• W2086041829 countsByYear W20860418292018 @default.
• W2086041829 countsByYear W20860418292019 @default.
• W2086041829 countsByYear W20860418292020 @default.
• W2086041829 countsByYear W20860418292021 @default.
• W2086041829 countsByYear W20860418292022 @default.
• W2086041829 countsByYear W20860418292023 @default.
• W2086041829 crossrefType "journal-article" @default.
• W2086041829 hasAuthorship W2086041829A5001240923 @default.
• W2086041829 hasAuthorship W2086041829A5008454281 @default.
• W2086041829 hasAuthorship W2086041829A5019098800 @default.
• W2086041829 hasAuthorship W2086041829A5020397435 @default.
• W2086041829 hasAuthorship W2086041829A5038507730 @default.
• W2086041829 hasAuthorship W2086041829A5047849578 @default.
• W2086041829 hasAuthorship W2086041829A5066380904 @default.
• W2086041829 hasBestOaLocation W20860418291 @default.
• W2086041829 hasConcept C101762097 @default.
• W2086041829 hasConcept C104317684 @default.
• W2086041829 hasConcept C118552586 @default.

• next