FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086046051> ?p ?o ?g. }

• W2086046051 endingPage "3225" @default.
• W2086046051 startingPage "3213" @default.
• W2086046051 abstract "Directed differentiation and purification of mesencephalic dopaminergic (mesDA) neurons from stem cells are crucial issues for realizing safe and efficient cell transplantation therapies for Parkinson's disease. Although recent studies have identified the factors that regulate mesDA neuron development, the mechanisms underlying mesDA neuron specification are not fully understood. Recently, it has been suggested that mesencephalic floor plate (FP) cells acquire neural progenitor characteristics to generate mesDA neurons. Here, we directly examined this in a fate mapping experiment using fluorescence-activated cell sorting (FACS) with an FP cell-specific surface marker, and demonstrate that mesencephalic FP cells have neurogenic activity and generate mesDA neurons in vitro. By contrast, sorted caudal FP cells have no neurogenic potential, as previously thought. Analysis of dreher mutant mice carrying a mutation in the Lmx1a locus and transgenic mice ectopically expressing Otx2 in caudal FP cells demonstrated that Otx2 determines anterior identity that confers neurogenic activity to FP cells and specifies a mesDA fate, at least in part through the induction of Lmx1a. We further show that FACS can isolate mesDA progenitors, a suitable transplantation material, from embryonic stem cell-derived neural cells. Our data provide insights into the mechanisms of specification and generation of mesDA neurons, and illustrate a useful cell replacement approach for Parkinson's disease." @default.
• W2086046051 created "2016-06-24" @default.
• W2086046051 creator A5004829893 @default.
• W2086046051 creator A5016250638 @default.
• W2086046051 creator A5016768252 @default.
• W2086046051 creator A5026198811 @default.
• W2086046051 creator A5027763231 @default.
• W2086046051 creator A5032974579 @default.
• W2086046051 creator A5035253393 @default.
• W2086046051 creator A5037287387 @default.
• W2086046051 creator A5053407094 @default.
• W2086046051 creator A5068542492 @default.
• W2086046051 creator A5079880806 @default.
• W2086046051 creator A5080121331 @default.
• W2086046051 date "2007-09-01" @default.
• W2086046051 modified "2023-10-14" @default.
• W2086046051 title "Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells" @default.
• W2086046051 cites W1609321187 @default.
• W2086046051 cites W1650647918 @default.
• W2086046051 cites W1960015501 @default.
• W2086046051 cites W1966476278 @default.
• W2086046051 cites W1970642341 @default.
• W2086046051 cites W1981437331 @default.
• W2086046051 cites W1983274440 @default.
• W2086046051 cites W1993736057 @default.
• W2086046051 cites W2000258781 @default.
• W2086046051 cites W2014077626 @default.
• W2086046051 cites W2015838461 @default.
• W2086046051 cites W2016085626 @default.
• W2086046051 cites W2017000463 @default.
• W2086046051 cites W2021788942 @default.
• W2086046051 cites W2031455229 @default.
• W2086046051 cites W2048833489 @default.
• W2086046051 cites W2050215340 @default.
• W2086046051 cites W2062277719 @default.
• W2086046051 cites W2062457936 @default.
• W2086046051 cites W2071193374 @default.
• W2086046051 cites W2075453897 @default.
• W2086046051 cites W2081235375 @default.
• W2086046051 cites W2084412384 @default.
• W2086046051 cites W2090661065 @default.
• W2086046051 cites W2111191613 @default.
• W2086046051 cites W2111525324 @default.
• W2086046051 cites W2139168265 @default.
• W2086046051 cites W2143959688 @default.
• W2086046051 cites W2148512749 @default.
• W2086046051 cites W2150235329 @default.
• W2086046051 cites W4231677736 @default.
• W2086046051 cites W4376633690 @default.
• W2086046051 doi "https://doi.org/10.1242/dev.02879" @default.
• W2086046051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17670789" @default.
• W2086046051 hasPublicationYear "2007" @default.
• W2086046051 type Work @default.
• W2086046051 sameAs 2086046051 @default.
• W2086046051 citedByCount "286" @default.
• W2086046051 countsByYear W20860460512012 @default.
• W2086046051 countsByYear W20860460512013 @default.
• W2086046051 countsByYear W20860460512014 @default.
• W2086046051 countsByYear W20860460512015 @default.
• W2086046051 countsByYear W20860460512016 @default.
• W2086046051 countsByYear W20860460512017 @default.
• W2086046051 countsByYear W20860460512018 @default.
• W2086046051 countsByYear W20860460512019 @default.
• W2086046051 countsByYear W20860460512020 @default.
• W2086046051 countsByYear W20860460512021 @default.
• W2086046051 countsByYear W20860460512022 @default.
• W2086046051 countsByYear W20860460512023 @default.
• W2086046051 crossrefType "journal-article" @default.
• W2086046051 hasAuthorship W2086046051A5004829893 @default.
• W2086046051 hasAuthorship W2086046051A5016250638 @default.
• W2086046051 hasAuthorship W2086046051A5016768252 @default.
• W2086046051 hasAuthorship W2086046051A5026198811 @default.
• W2086046051 hasAuthorship W2086046051A5027763231 @default.
• W2086046051 hasAuthorship W2086046051A5032974579 @default.
• W2086046051 hasAuthorship W2086046051A5035253393 @default.
• W2086046051 hasAuthorship W2086046051A5037287387 @default.
• W2086046051 hasAuthorship W2086046051A5053407094 @default.
• W2086046051 hasAuthorship W2086046051A5068542492 @default.
• W2086046051 hasAuthorship W2086046051A5079880806 @default.
• W2086046051 hasAuthorship W2086046051A5080121331 @default.
• W2086046051 hasConcept C104317684 @default.
• W2086046051 hasConcept C124964019 @default.
• W2086046051 hasConcept C126322002 @default.
• W2086046051 hasConcept C136834591 @default.
• W2086046051 hasConcept C145103041 @default.
• W2086046051 hasConcept C148738053 @default.
• W2086046051 hasConcept C1491633281 @default.
• W2086046051 hasConcept C15729860 @default.
• W2086046051 hasConcept C163952510 @default.
• W2086046051 hasConcept C169760540 @default.
• W2086046051 hasConcept C189014844 @default.
• W2086046051 hasConcept C201750760 @default.
• W2086046051 hasConcept C2778630268 @default.
• W2086046051 hasConcept C2778794669 @default.
• W2086046051 hasConcept C28328180 @default.
• W2086046051 hasConcept C2911091166 @default.
• W2086046051 hasConcept C529278444 @default.
• W2086046051 hasConcept C54355233 @default.

• next