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• W2086046353 abstract "Summary. The mechanism through which DDAVP (1‐deamino‐8‐ d ‐arginine vasopressin) promotes blood coagulation is not completely understood. As blood monocytes have been identified as a target for DDAVP, we investigated whether this drug increased monocyte adhesion to activated platelets, which would result in the close intercellular contact that is necessary for a juxtacrine effect on platelets and/or endothelium at sites of vascular injury. Monolayers of non‐confluent monocytes adhered to glass slides were incubated with thrombin‐activated, formaldehyde‐fixed platelets before and after the adherent monocytes were stimulated with DDAVP or n‐formyl‐methyl‐leucyl‐phenylalanine (fMLP). The number of platelets involved in rosettes with monocytes was quantified, and the effect of DDAVP or fMLP on the monocyte surface expression of P‐selectin ligands and CD11b/CD18 was assessed. DDAVP or fMLP increased the number of activated platelets involved in rosettes with monocytes by 2·8‐ and 4·9‐fold respectively. EDTA and inhibitors of the P‐selectin/counter‐receptor interaction decreased the platelet numbers in rosettes by 80–90%, whereas inhibitors of the integrin‐mediated adhesion reduced rosettes by 40–50%. Blocking the P‐selectin glycoprotein ligand‐1 (PSGL‐1) with the monoclonal antibody, Pl‐1, decreased the platelet numbers in rosettes by only 50%. In contrast, surface expression of the sialylated ligands of P‐selectin and, to a lesser extent, of CD11b/CD18 increased upon monocyte activation with DDAVP or fMLP, whereas it decreased slightly with PSGL‐1. These results indicate that DDAVP enhanced the ability of blood monocytes to bind activated platelets, mainly by increasing the expression of P‐selectin sialylated ligands on the monocyte surface. A similar effect was achieved with fMLP." @default.
• W2086046353 created "2016-06-24" @default.
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• W2086046353 date "2003-03-01" @default.
• W2086046353 modified "2023-10-16" @default.
• W2086046353 title "DDAVP enhances the ability of blood monocytes to form rosettes with activated platelets by increasing the expression of P-selectin sialylated ligands on the monocyte surface" @default.
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• W2086046353 doi "https://doi.org/10.1046/j.1365-2141.2003.04180.x" @default.
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