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• W2086047523 abstract "The present study was designed to investigate the effect of U50488H, a prototype non-peptide kappa opioid agonist on convulsive behaviour using a maximal electroshock (MES) seizure test in mice. An attempt was also made to explore the role of possible receptors involved. MES seizures were induced via transauricular electrodes (60 mA, 0.2 s). Seizure severity was evaluated by means of two parameters, i.e., (1) duration of tonic hindlimb extensor phase and (2) mortality due to convulsions. Intraperitoneal (ip) administration of U50488H dose dependently (5–20 mg/kg) decreased the hindlimb extensor phase of MES. The anticonvulsant effect of U50488H was attenuated by the general opioid antagonist, naloxone at a high dose, and by MR2266, a selective kappa antagonist, but not by naltrindole, a delta antagonist. Coadministration of γ-aminobutyric acid (GABA)ergic drugs (diazepam, GABA, muscimol, and baclofen) and the N-methyl-d-aspartate (NMDA) receptor antagonist, dizocilpine (MK801), with U50488H augmented the anticonvulsant effect of the latter drug in mice. On the other hand, flumazenil, a central benzodiazepine (BZD) receptor antagonist, reversed the protective effect of diazepam and similarly, δ-aminovaleric acid (DAVA), a GABAB receptor antagonist, blocked the protective effect of baclofen, a GABAB agonist on the anti-MES action of U50488H. These BZD–GABAergic antagonists, namely, flumazenil or DAVA, on their own also counteracted the anti-electroshock seizure effect of U50488H given alone. However, mortality was not significantly altered in any of the above animal groups. Taken together, the findings have shown a possible role for multitude of important neurotransmitter systems, i.e., opioid (kappa), NMDA channel, GABAA–BZD-chloride channel complex, and GABAB receptors in the anticonvulsant action of U50488H." @default.
• W2086047523 created "2016-06-24" @default.
• W2086047523 creator A5069017801 @default.
• W2086047523 date "2003-08-01" @default.
• W2086047523 modified "2023-09-30" @default.
• W2086047523 title "Studies on the anticonvulsant effect of U50488H on maximal electroshock seizure in mice" @default.
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• W2086047523 doi "https://doi.org/10.1016/s0091-3057(03)00218-1" @default.
• W2086047523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13679223" @default.
• W2086047523 hasPublicationYear "2003" @default.
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