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- W2086048382 abstract "Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulatory ligand that terminates the lifecycle of the low-density lipoprotein (LDL) receptor (LDLR) thus affecting plasma LDL-cholesterol (LDL-C) levels. Recent evidence shows that in addition to the straightforward mechanism of action, there are more complex interactions between PCSK9, LDLR and plasma lipoprotein levels, including: (a) the presence of both parallel and reciprocal regulation of surface LDLR and plasma PCSK9; (b) a correlation between PCSK9 and LDL-C levels dependent not only on the fact that PCSK9 removes hepatic LDLR, but also due to the fact that up to 40% of plasma PCSK9 is physically associated with LDL; and (c) an association between plasma PCSK9 production and the assembly and secretion of triglyceride-rich lipoproteins. The effect of PCSK9 on LDLR is being successfully utilized toward the development of anti-PCSK9 therapies to reduce plasma LDL-C levels. Current biochemical research has uncovered additional mechanisms of action and interacting partners for PCSK9, and this opens the way for a more thorough understanding of the regulation, metabolism, and effects of this interesting protein." @default.
- W2086048382 created "2016-06-24" @default.
- W2086048382 creator A5002707863 @default.
- W2086048382 creator A5067797353 @default.
- W2086048382 creator A5068826784 @default.
- W2086048382 date "2015-02-01" @default.
- W2086048382 modified "2023-10-01" @default.
- W2086048382 title "On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects" @default.
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- W2086048382 doi "https://doi.org/10.1016/j.atherosclerosis.2014.12.017" @default.
- W2086048382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562333" @default.
- W2086048382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25544176" @default.
- W2086048382 hasPublicationYear "2015" @default.
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