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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086052011> ?p ?o ?g. }

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• W2086052011 abstract "A novel class of non-peptide somatostatin receptor ligands bearing the octahydrobenzo[g]quinoline (obeline) structural element has been identified. SAR studies have been performed that led to the discovery of derivatives with high affinity (pK(d) r sst(1) > or = 9) and selectivity (> or = 150-fold for h sst(1) over h sst(2)-h sst(5)) for somatostatin receptor subtype sst(1). In a functional assay, the compounds act as antagonists at human recombinant sst(1) receptors." @default.
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• W2086052011 date "2007-07-01" @default.
• W2086052011 modified "2023-09-28" @default.
• W2086052011 title "Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists" @default.
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• W2086052011 doi "https://doi.org/10.1016/j.bmcl.2007.04.086" @default.
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