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- W2086054992 abstract "Abstract The site of guanidine action on poliovirus type 2 was investigated. Physical-chemical and biological characterizations of viral mutants with altered guanidine sensitivities indicate changes in capsid polypeptides. Differences between mutants include electrophoretic mobilities of virions and of capsid subunits, stability of virions to high temperature, and chromatographic behavior of individual capsid polypeptides. No alterations were detected in nonstructural proteins of guanidine mutants. Aside from guanidine sensitivity of RNA synthesis, the differences between mutants in replication were limited to early events, particularly uncoating rates. No evidence for an effect of guanidine on processed capsid polypeptides was obtained; however, the capsid precursor polypeptide of sensitive virus is altered by guanidine treatment. A model is proposed in which a precursor to poliovirus structural polypeptides participates in viral RNA synthesis." @default.
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- W2086054992 date "1977-08-01" @default.
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- W2086054992 title "Poliovirus coat protein as the site of guanidine action" @default.
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- W2086054992 doi "https://doi.org/10.1016/0042-6822(77)90055-1" @default.
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