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- W2086071710 abstract "Considerable attention has always been paid to the possibility that tumour formation, either spontaneous or experimental, might be influenced by nutritional conditions in the host. In this connection special interest seemed attached to reports by Davidson (1934, 1935) that a diet rich in vitamin E inhibited the development of tar cancer in mice.Two further observations may bear some relation to this problem. Evans (1928) described the high incidence of deciduomata during pseudopregnancy in rats maintained on a diet deficient in vitamin E. More recently Adamstone (1934) discussed a possible relationship of vitamin E to unrestricted cell division. In his experiments a deficient diet—freed from the vitamin by a modification of the Waddell-Steenbock method—was fed to chicks over a prolonged period. The treatment resulted in the development of characteristic visceral lesions represented by “foci of degeneration and destruction of normal tissues accompanied by replacement and invasion by new cell growths, …” This Adamstone regarded as an example of uncontrolled cell growth simulating malignancy, and he suggested that vitamin E is so essential for the maintenance of the normal nuclear condition that it acts indirectly as a control over cell division.In view of these suggestions it was decided to investigate the effect of a diet supplemented with wheat germ oil on the production of skin tumours in mice by means of 3:4-benzpyrene (Cook, Hewett and Hieger, 1933). It must be made clear that Davidson related the phenomenon he described simply to the addition of wheat germ oil and not necessarily to the content of the oil in vitamin E." @default.
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- W2086071710 date "1937-02-01" @default.
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- W2086071710 title "The Influence of Wheat Germ Oil in the Diet on the Induction of Tumours in Mice" @default.
- W2086071710 doi "https://doi.org/10.1158/ajc.1937.363" @default.
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