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- W2086071777 abstract "Trifunctional antibodies (trAbs) are promising novel anticancer biologics with a particular mode of action capable of linking innate with adaptive immunity. Based on their unique structure, trifunctional IgG-like heterodimeric antibodies, consisting of nonhuman mouse and rat immunoglobulin halves are able to redirect T lymphocytes, as well as accessory cells, to the tumor site. This recruitment of immune cells is accompanied by cellular activation events elicited by anti-CD3, as well as Fcγ-receptor engagement of trAbs supported by a proinflammatory Th1-biased cytokine milieu. All necessary immunological factors required for long-term vaccination-like effects are stimulated along trAb-mediated therapeutic interventions. Thus, the concerted interplay of antibody-dependent cellular cytotoxicity plus the polyclonal T-cell cytotoxicity and Fcγ-receptor-driven induction of long-lasting immune responses after the initial tumor cell elimination represent the major hallmarks of trAb-mediated treatment of malignant diseases." @default.
- W2086071777 created "2016-06-24" @default.
- W2086071777 creator A5063435247 @default.
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- W2086071777 date "2012-01-01" @default.
- W2086071777 modified "2023-09-23" @default.
- W2086071777 title "Cancer therapy with trifunctional antibodies: linking innate and adaptive immunity" @default.
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- W2086071777 doi "https://doi.org/10.2217/fon.11.138" @default.
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