Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086075008> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2086075008 endingPage "124" @default.
- W2086075008 startingPage "119" @default.
- W2086075008 abstract "The substrate specificity of mouse recombinant phenylalanine monooxygenase (mPAH) has been investigated with respect to the mucoactive drug, S-carboxymethyl-L-cysteine (SCMC) and its thioether metabolites. Phenylalanine monooxygenase was shown to be able to catalyze the S-oxygenation of SCMC, its decarboxylated metabolite, S-methyl-L-cysteine and both their corresponding N-acetylated forms. However, thiodiglycolic acid was found not to be a substrate. The enzyme profiles for both phenylalanine and SCMC showed Michaelis-Menten with noncompetitive substrate inhibition for both the substrate-activated and the lysophosphatidylcholine-activated mPAH assays. The tetrameric enzyme was shown to undergo posttranslational activation by preincubation with substrate, lysophosphatidylcholine, N-ethylmaleimide (a thiol alkylating agent), and the proteolytic enzymes α-chymotrypsin and trypsin. Similar posttranslational activation of PAH activity in the rat and human has also been reported. These results suggest that in the mouse, PAH was responsible for the S-oxidation of SCMC and that the mouse models of the hyperphenylalaninemias may be a potential tool in the investigation of the S-oxidation polymorphism in man. © 2009 Wiley Periodicals, Inc. J Biochem Mol Toxicol 23:119–124, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20274" @default.
- W2086075008 created "2016-06-24" @default.
- W2086075008 creator A5001516751 @default.
- W2086075008 creator A5081826044 @default.
- W2086075008 date "2009-03-01" @default.
- W2086075008 modified "2023-09-24" @default.
- W2086075008 title "Mouse recombinant phenylalanine monooxygenase and theS-oxygenation of thioether substrates" @default.
- W2086075008 cites W1529181216 @default.
- W2086075008 cites W1576536837 @default.
- W2086075008 cites W1595183559 @default.
- W2086075008 cites W1816125786 @default.
- W2086075008 cites W1912102954 @default.
- W2086075008 cites W1970245266 @default.
- W2086075008 cites W1985926038 @default.
- W2086075008 cites W1989354361 @default.
- W2086075008 cites W1991513126 @default.
- W2086075008 cites W1992460598 @default.
- W2086075008 cites W1993207768 @default.
- W2086075008 cites W1998925389 @default.
- W2086075008 cites W2004021775 @default.
- W2086075008 cites W2027766446 @default.
- W2086075008 cites W2063756503 @default.
- W2086075008 cites W2075041169 @default.
- W2086075008 cites W2091764336 @default.
- W2086075008 cites W2160583678 @default.
- W2086075008 cites W2404242464 @default.
- W2086075008 cites W4239353631 @default.
- W2086075008 cites W2032870272 @default.
- W2086075008 cites W2087159199 @default.
- W2086075008 doi "https://doi.org/10.1002/jbt.20274" @default.
- W2086075008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19367645" @default.
- W2086075008 hasPublicationYear "2009" @default.
- W2086075008 type Work @default.
- W2086075008 sameAs 2086075008 @default.
- W2086075008 citedByCount "9" @default.
- W2086075008 countsByYear W20860750082012 @default.
- W2086075008 countsByYear W20860750082015 @default.
- W2086075008 countsByYear W20860750082018 @default.
- W2086075008 countsByYear W20860750082019 @default.
- W2086075008 crossrefType "journal-article" @default.
- W2086075008 hasAuthorship W2086075008A5001516751 @default.
- W2086075008 hasAuthorship W2086075008A5081826044 @default.
- W2086075008 hasConcept C13002179 @default.
- W2086075008 hasConcept C181199279 @default.
- W2086075008 hasConcept C185592680 @default.
- W2086075008 hasConcept C18903297 @default.
- W2086075008 hasConcept C2776146729 @default.
- W2086075008 hasConcept C2777289219 @default.
- W2086075008 hasConcept C2777303428 @default.
- W2086075008 hasConcept C2777431362 @default.
- W2086075008 hasConcept C2779201268 @default.
- W2086075008 hasConcept C2779444094 @default.
- W2086075008 hasConcept C515207424 @default.
- W2086075008 hasConcept C526171541 @default.
- W2086075008 hasConcept C55493867 @default.
- W2086075008 hasConcept C71240020 @default.
- W2086075008 hasConcept C86803240 @default.
- W2086075008 hasConceptScore W2086075008C13002179 @default.
- W2086075008 hasConceptScore W2086075008C181199279 @default.
- W2086075008 hasConceptScore W2086075008C185592680 @default.
- W2086075008 hasConceptScore W2086075008C18903297 @default.
- W2086075008 hasConceptScore W2086075008C2776146729 @default.
- W2086075008 hasConceptScore W2086075008C2777289219 @default.
- W2086075008 hasConceptScore W2086075008C2777303428 @default.
- W2086075008 hasConceptScore W2086075008C2777431362 @default.
- W2086075008 hasConceptScore W2086075008C2779201268 @default.
- W2086075008 hasConceptScore W2086075008C2779444094 @default.
- W2086075008 hasConceptScore W2086075008C515207424 @default.
- W2086075008 hasConceptScore W2086075008C526171541 @default.
- W2086075008 hasConceptScore W2086075008C55493867 @default.
- W2086075008 hasConceptScore W2086075008C71240020 @default.
- W2086075008 hasConceptScore W2086075008C86803240 @default.
- W2086075008 hasIssue "2" @default.
- W2086075008 hasLocation W20860750081 @default.
- W2086075008 hasLocation W20860750082 @default.
- W2086075008 hasOpenAccess W2086075008 @default.
- W2086075008 hasPrimaryLocation W20860750081 @default.
- W2086075008 hasRelatedWork W1569106110 @default.
- W2086075008 hasRelatedWork W1967590977 @default.
- W2086075008 hasRelatedWork W1981229103 @default.
- W2086075008 hasRelatedWork W1987227757 @default.
- W2086075008 hasRelatedWork W2053583806 @default.
- W2086075008 hasRelatedWork W2055038395 @default.
- W2086075008 hasRelatedWork W2086075008 @default.
- W2086075008 hasRelatedWork W2118180263 @default.
- W2086075008 hasRelatedWork W2155715604 @default.
- W2086075008 hasRelatedWork W4235214609 @default.
- W2086075008 hasVolume "23" @default.
- W2086075008 isParatext "false" @default.
- W2086075008 isRetracted "false" @default.
- W2086075008 magId "2086075008" @default.
- W2086075008 workType "article" @default.