FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086076478> ?p ?o ?g. }

• W2086076478 endingPage "2421" @default.
• W2086076478 startingPage "2416" @default.
• W2086076478 abstract "The development and cooperation of distinct subsets of antigen-presenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much attention has been focused on IFN-alpha/beta, the cytokines induced en masse by virus infection or the activation of Toll-like receptors, in the context of DC activation. Here, we show that mice deficient in IFN regulatory factor 2 exhibit selective loss of CD8alpha- DCs, the so-called myeloid DCs, which is accompanied by a notable increase in CD11c-CD11bhigh other myeloid lineage cells. Such deficiency is intrinsic to the bone marrow precursors, in which the abnormal induction of IFN-alpha/beta genes causes excessive IFN signaling. The critical function of IFN regulatory factor 2 in the negative regulation of IFN-alpha/beta signaling is underscored by the observation that the deficiency is rescued by introducing an additional null mutation for the IFN receptor complex. In view of accumulating evidence of the critical role of IFN-alpha/beta signaling in DC activation, our present study offers a unique example in that the magnitude of a cytokine signal should be properly balanced in a stage-specific manner during the differentiation and activation of DCs." @default.
• W2086076478 created "2016-06-24" @default.
• W2086076478 creator A5043774822 @default.
• W2086076478 creator A5072790141 @default.
• W2086076478 creator A5084422123 @default.
• W2086076478 date "2004-02-11" @default.
• W2086076478 modified "2023-09-30" @default.
• W2086076478 title "Negative regulation of IFN-α/β signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells" @default.
• W2086076478 cites W1661544713 @default.
• W2086076478 cites W1967879964 @default.
• W2086076478 cites W1981743414 @default.
• W2086076478 cites W1996350333 @default.
• W2086076478 cites W1996790111 @default.
• W2086076478 cites W1997512963 @default.
• W2086076478 cites W2003236494 @default.
• W2086076478 cites W2004829503 @default.
• W2086076478 cites W2005115869 @default.
• W2086076478 cites W2006585212 @default.
• W2086076478 cites W2016525911 @default.
• W2086076478 cites W2018718597 @default.
• W2086076478 cites W2021112267 @default.
• W2086076478 cites W2029275361 @default.
• W2086076478 cites W2030528311 @default.
• W2086076478 cites W2048143404 @default.
• W2086076478 cites W2065085347 @default.
• W2086076478 cites W2065086280 @default.
• W2086076478 cites W2065661920 @default.
• W2086076478 cites W2072075206 @default.
• W2086076478 cites W2089077517 @default.
• W2086076478 cites W2089140732 @default.
• W2086076478 cites W2092386544 @default.
• W2086076478 cites W2094504570 @default.
• W2086076478 cites W2101392460 @default.
• W2086076478 cites W2101642059 @default.
• W2086076478 cites W2102204735 @default.
• W2086076478 cites W2105089699 @default.
• W2086076478 cites W2106315019 @default.
• W2086076478 cites W2108399976 @default.
• W2086076478 cites W2108765339 @default.
• W2086076478 cites W2120783853 @default.
• W2086076478 cites W2123076394 @default.
• W2086076478 cites W2142356948 @default.
• W2086076478 cites W2150564865 @default.
• W2086076478 cites W2153624732 @default.
• W2086076478 cites W2154379321 @default.
• W2086076478 cites W2156049473 @default.
• W2086076478 cites W2162137343 @default.
• W2086076478 cites W2166676682 @default.
• W2086076478 cites W2314579246 @default.
• W2086076478 cites W2403681274 @default.
• W2086076478 doi "https://doi.org/10.1073/pnas.0307336101" @default.
• W2086076478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/356965" @default.
• W2086076478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14983024" @default.
• W2086076478 hasPublicationYear "2004" @default.
• W2086076478 type Work @default.
• W2086076478 sameAs 2086076478 @default.
• W2086076478 citedByCount "93" @default.
• W2086076478 countsByYear W20860764782012 @default.
• W2086076478 countsByYear W20860764782013 @default.
• W2086076478 countsByYear W20860764782014 @default.
• W2086076478 countsByYear W20860764782015 @default.
• W2086076478 countsByYear W20860764782016 @default.
• W2086076478 countsByYear W20860764782018 @default.
• W2086076478 countsByYear W20860764782019 @default.
• W2086076478 countsByYear W20860764782020 @default.
• W2086076478 countsByYear W20860764782021 @default.
• W2086076478 countsByYear W20860764782022 @default.
• W2086076478 countsByYear W20860764782023 @default.
• W2086076478 crossrefType "journal-article" @default.
• W2086076478 hasAuthorship W2086076478A5043774822 @default.
• W2086076478 hasAuthorship W2086076478A5072790141 @default.
• W2086076478 hasAuthorship W2086076478A5084422123 @default.
• W2086076478 hasBestOaLocation W20860764781 @default.
• W2086076478 hasConcept C104317684 @default.
• W2086076478 hasConcept C117705580 @default.
• W2086076478 hasConcept C127716648 @default.
• W2086076478 hasConcept C203014093 @default.
• W2086076478 hasConcept C2778690821 @default.
• W2086076478 hasConcept C2779919695 @default.
• W2086076478 hasConcept C54355233 @default.
• W2086076478 hasConcept C62478195 @default.
• W2086076478 hasConcept C63645605 @default.
• W2086076478 hasConcept C86339819 @default.
• W2086076478 hasConcept C86803240 @default.
• W2086076478 hasConcept C8891405 @default.
• W2086076478 hasConcept C95444343 @default.
• W2086076478 hasConceptScore W2086076478C104317684 @default.
• W2086076478 hasConceptScore W2086076478C117705580 @default.
• W2086076478 hasConceptScore W2086076478C127716648 @default.
• W2086076478 hasConceptScore W2086076478C203014093 @default.
• W2086076478 hasConceptScore W2086076478C2778690821 @default.
• W2086076478 hasConceptScore W2086076478C2779919695 @default.
• W2086076478 hasConceptScore W2086076478C54355233 @default.
• W2086076478 hasConceptScore W2086076478C62478195 @default.
• W2086076478 hasConceptScore W2086076478C63645605 @default.
• W2086076478 hasConceptScore W2086076478C86339819 @default.
• W2086076478 hasConceptScore W2086076478C86803240 @default.
• W2086076478 hasConceptScore W2086076478C8891405 @default.

• next