Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086078940> ?p ?o ?g. }
- W2086078940 endingPage "1302" @default.
- W2086078940 startingPage "1294" @default.
- W2086078940 abstract "The expression of functional GABA(A)-receptors in glioma cells correlates with low malignancy of tumours and cell lines from glioma lack these receptors. Here we show that contact with neurons induces the expression of functional GABA(A)-receptors. C6 and F98 glioma cell lines were labelled by recombinant expression of enhanced green fluorescent protein injected into rat brain and studied in acute slices after two to three weeks of tumour growth. The cells responded to GABA or the specific agonist, muscimol with a current typical for GABA(A)-receptors, as studied with the patch-clamp technique. To get insight into the mechanism of GABA(A) receptor induction, the C6 or F98 cells were co-cultured with neurons, astrocytes, oligodendrocytes and microglia. Glioma cells expressed functional GABA(A) receptors within 24 h only in cultures where physical contact to neurons occurred. Activation of GABA(A)-receptors in the co-cultures attenuated glioma cell metabolism while blockade of the receptors increased metabolism. We conclude that with this form of interaction, neurons can influence tumour behaviour in the brain." @default.
- W2086078940 created "2016-06-24" @default.
- W2086078940 creator A5003009183 @default.
- W2086078940 creator A5009493618 @default.
- W2086078940 creator A5011095752 @default.
- W2086078940 creator A5020369086 @default.
- W2086078940 creator A5028089820 @default.
- W2086078940 creator A5073484816 @default.
- W2086078940 creator A5082118692 @default.
- W2086078940 creator A5085312364 @default.
- W2086078940 creator A5086549313 @default.
- W2086078940 date "2001-10-01" @default.
- W2086078940 modified "2023-10-16" @default.
- W2086078940 title "GABA<sub>A</sub>-receptor expression in glioma cells is triggered by contact with neuronal cells" @default.
- W2086078940 cites W1607927414 @default.
- W2086078940 cites W1646206347 @default.
- W2086078940 cites W1674534725 @default.
- W2086078940 cites W191454705 @default.
- W2086078940 cites W1964038642 @default.
- W2086078940 cites W1968744347 @default.
- W2086078940 cites W1969596324 @default.
- W2086078940 cites W1981160088 @default.
- W2086078940 cites W1981792999 @default.
- W2086078940 cites W1984894292 @default.
- W2086078940 cites W1985271131 @default.
- W2086078940 cites W1992233256 @default.
- W2086078940 cites W1998225973 @default.
- W2086078940 cites W2009667219 @default.
- W2086078940 cites W2013144333 @default.
- W2086078940 cites W2027253281 @default.
- W2086078940 cites W2035711252 @default.
- W2086078940 cites W2049468392 @default.
- W2086078940 cites W2055000764 @default.
- W2086078940 cites W2057140644 @default.
- W2086078940 cites W2059994807 @default.
- W2086078940 cites W2060075467 @default.
- W2086078940 cites W2071743480 @default.
- W2086078940 cites W2072883274 @default.
- W2086078940 cites W2081083251 @default.
- W2086078940 cites W2086968375 @default.
- W2086078940 cites W2091707080 @default.
- W2086078940 cites W2108129164 @default.
- W2086078940 cites W2126707307 @default.
- W2086078940 cites W2159350004 @default.
- W2086078940 cites W2165924603 @default.
- W2086078940 cites W307528205 @default.
- W2086078940 cites W4245486276 @default.
- W2086078940 cites W4319308373 @default.
- W2086078940 cites W9043722 @default.
- W2086078940 doi "https://doi.org/10.1046/j.0953-816x.2001.01764.x" @default.
- W2086078940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11703458" @default.
- W2086078940 hasPublicationYear "2001" @default.
- W2086078940 type Work @default.
- W2086078940 sameAs 2086078940 @default.
- W2086078940 citedByCount "29" @default.
- W2086078940 countsByYear W20860789402012 @default.
- W2086078940 countsByYear W20860789402015 @default.
- W2086078940 countsByYear W20860789402016 @default.
- W2086078940 countsByYear W20860789402019 @default.
- W2086078940 countsByYear W20860789402021 @default.
- W2086078940 countsByYear W20860789402023 @default.
- W2086078940 crossrefType "journal-article" @default.
- W2086078940 hasAuthorship W2086078940A5003009183 @default.
- W2086078940 hasAuthorship W2086078940A5009493618 @default.
- W2086078940 hasAuthorship W2086078940A5011095752 @default.
- W2086078940 hasAuthorship W2086078940A5020369086 @default.
- W2086078940 hasAuthorship W2086078940A5028089820 @default.
- W2086078940 hasAuthorship W2086078940A5073484816 @default.
- W2086078940 hasAuthorship W2086078940A5082118692 @default.
- W2086078940 hasAuthorship W2086078940A5085312364 @default.
- W2086078940 hasAuthorship W2086078940A5086549313 @default.
- W2086078940 hasConcept C147944092 @default.
- W2086078940 hasConcept C168258287 @default.
- W2086078940 hasConcept C169760540 @default.
- W2086078940 hasConcept C170493617 @default.
- W2086078940 hasConcept C185592680 @default.
- W2086078940 hasConcept C203014093 @default.
- W2086078940 hasConcept C2776914184 @default.
- W2086078940 hasConcept C2778227246 @default.
- W2086078940 hasConcept C2778938600 @default.
- W2086078940 hasConcept C2779188335 @default.
- W2086078940 hasConcept C2779830541 @default.
- W2086078940 hasConcept C2993002077 @default.
- W2086078940 hasConcept C502942594 @default.
- W2086078940 hasConcept C54355233 @default.
- W2086078940 hasConcept C55493867 @default.
- W2086078940 hasConcept C81885089 @default.
- W2086078940 hasConcept C86803240 @default.
- W2086078940 hasConcept C95444343 @default.
- W2086078940 hasConceptScore W2086078940C147944092 @default.
- W2086078940 hasConceptScore W2086078940C168258287 @default.
- W2086078940 hasConceptScore W2086078940C169760540 @default.
- W2086078940 hasConceptScore W2086078940C170493617 @default.
- W2086078940 hasConceptScore W2086078940C185592680 @default.
- W2086078940 hasConceptScore W2086078940C203014093 @default.
- W2086078940 hasConceptScore W2086078940C2776914184 @default.
- W2086078940 hasConceptScore W2086078940C2778227246 @default.
- W2086078940 hasConceptScore W2086078940C2778938600 @default.