FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086081421> ?p ?o ?g. }

• W2086081421 endingPage "1470" @default.
• W2086081421 startingPage "1465" @default.
• W2086081421 abstract "Uric acid and the state of the intrarenal renin-angiotensin system in humans.BackgroundExperimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system (RAS). The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity. We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II.MethodsA total of 249 subjects in high sodium balance had the renal plasma flow (RPF) response to Ang II measured. Para-aminohippuric acid (PAH) clearance was used to estimate RPF. Multivariable regression analysis determined if the serum uric acid concentration independently predicts the RPF response to Ang II. Variables considered included age, gender, race, body mass index (BMI), hypertension status, blood pressure, basal RPF, creatinine clearance, serum insulin, serum glucose, serum high-density lipoprotein (HDL), serum triglycerides, and plasma renin activity (PRA).ResultsUric acid concentration negatively correlated with the RPF response to Ang II (r=-0.37, P < 0.001). In univariate analysis, age, BMI, hypertension, triglycerides, and blood pressure were negatively associated, and basal RPF, HDL, and female gender were positively associated with the RPF response to Ang II. In multivariable analysis, serum uric acid concentration independently predicted the RPF response to Ang II (β=-5.3, P < 0.001).ConclusionSerum uric acid independently predicted blunted renal vascular responsiveness to Ang II, consistent with results from experimental hyperuricemia showing an activated intrarenal RAS. This could be due to a direct effect of uric acid or reflect a more fundamental renal process. These data may have relevance to the association of uric acid with risk for hypertension and nephropathy. Uric acid and the state of the intrarenal renin-angiotensin system in humans. Experimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system (RAS). The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity. We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II. A total of 249 subjects in high sodium balance had the renal plasma flow (RPF) response to Ang II measured. Para-aminohippuric acid (PAH) clearance was used to estimate RPF. Multivariable regression analysis determined if the serum uric acid concentration independently predicts the RPF response to Ang II. Variables considered included age, gender, race, body mass index (BMI), hypertension status, blood pressure, basal RPF, creatinine clearance, serum insulin, serum glucose, serum high-density lipoprotein (HDL), serum triglycerides, and plasma renin activity (PRA). Uric acid concentration negatively correlated with the RPF response to Ang II (r=-0.37, P < 0.001). In univariate analysis, age, BMI, hypertension, triglycerides, and blood pressure were negatively associated, and basal RPF, HDL, and female gender were positively associated with the RPF response to Ang II. In multivariable analysis, serum uric acid concentration independently predicted the RPF response to Ang II (β=-5.3, P < 0.001). Serum uric acid independently predicted blunted renal vascular responsiveness to Ang II, consistent with results from experimental hyperuricemia showing an activated intrarenal RAS. This could be due to a direct effect of uric acid or reflect a more fundamental renal process. These data may have relevance to the association of uric acid with risk for hypertension and nephropathy." @default.
• W2086081421 created "2016-06-24" @default.
• W2086081421 creator A5003287725 @default.
• W2086081421 creator A5029779433 @default.
• W2086081421 creator A5038329286 @default.
• W2086081421 creator A5047140893 @default.
• W2086081421 creator A5055618165 @default.
• W2086081421 creator A5061280915 @default.
• W2086081421 creator A5065954729 @default.
• W2086081421 creator A5073673284 @default.
• W2086081421 date "2004-10-01" @default.
• W2086081421 modified "2023-09-27" @default.
• W2086081421 title "Uric acid and the state of the intrarenal renin-angiotensin system in humans" @default.
• W2086081421 cites W1964198430 @default.
• W2086081421 cites W1964389139 @default.
• W2086081421 cites W1970930655 @default.
• W2086081421 cites W1983030165 @default.
• W2086081421 cites W1996417763 @default.
• W2086081421 cites W1999111122 @default.
• W2086081421 cites W2020241446 @default.
• W2086081421 cites W2028076671 @default.
• W2086081421 cites W2034450178 @default.
• W2086081421 cites W2035352126 @default.
• W2086081421 cites W2038726142 @default.
• W2086081421 cites W2043172105 @default.
• W2086081421 cites W2048113580 @default.
• W2086081421 cites W2054205498 @default.
• W2086081421 cites W2069730334 @default.
• W2086081421 cites W2076811463 @default.
• W2086081421 cites W2089530641 @default.
• W2086081421 cites W2090355660 @default.
• W2086081421 cites W2105767342 @default.
• W2086081421 cites W2106362601 @default.
• W2086081421 cites W2113528337 @default.
• W2086081421 cites W2114816889 @default.
• W2086081421 cites W2119329007 @default.
• W2086081421 cites W2120330318 @default.
• W2086081421 cites W2123162884 @default.
• W2086081421 cites W2132770461 @default.
• W2086081421 cites W2134667952 @default.
• W2086081421 cites W2144595157 @default.
• W2086081421 cites W2405323403 @default.
• W2086081421 cites W4235060789 @default.
• W2086081421 cites W4321429168 @default.
• W2086081421 doi "https://doi.org/10.1111/j.1523-1755.2004.00909.x" @default.
• W2086081421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15458439" @default.
• W2086081421 hasPublicationYear "2004" @default.
• W2086081421 type Work @default.
• W2086081421 sameAs 2086081421 @default.
• W2086081421 citedByCount "180" @default.
• W2086081421 countsByYear W20860814212012 @default.
• W2086081421 countsByYear W20860814212013 @default.
• W2086081421 countsByYear W20860814212014 @default.
• W2086081421 countsByYear W20860814212015 @default.
• W2086081421 countsByYear W20860814212016 @default.
• W2086081421 countsByYear W20860814212017 @default.
• W2086081421 countsByYear W20860814212018 @default.
• W2086081421 countsByYear W20860814212019 @default.
• W2086081421 countsByYear W20860814212020 @default.
• W2086081421 countsByYear W20860814212021 @default.
• W2086081421 countsByYear W20860814212022 @default.
• W2086081421 countsByYear W20860814212023 @default.
• W2086081421 crossrefType "journal-article" @default.
• W2086081421 hasAuthorship W2086081421A5003287725 @default.
• W2086081421 hasAuthorship W2086081421A5029779433 @default.
• W2086081421 hasAuthorship W2086081421A5038329286 @default.
• W2086081421 hasAuthorship W2086081421A5047140893 @default.
• W2086081421 hasAuthorship W2086081421A5055618165 @default.
• W2086081421 hasAuthorship W2086081421A5061280915 @default.
• W2086081421 hasAuthorship W2086081421A5065954729 @default.
• W2086081421 hasAuthorship W2086081421A5073673284 @default.
• W2086081421 hasBestOaLocation W20860814211 @default.
• W2086081421 hasConcept C126322002 @default.
• W2086081421 hasConcept C134018914 @default.
• W2086081421 hasConcept C138976137 @default.
• W2086081421 hasConcept C142225936 @default.
• W2086081421 hasConcept C159641895 @default.
• W2086081421 hasConcept C185592680 @default.
• W2086081421 hasConcept C198710026 @default.
• W2086081421 hasConcept C2779721657 @default.
• W2086081421 hasConcept C2779881121 @default.
• W2086081421 hasConcept C2780091579 @default.
• W2086081421 hasConcept C2780306776 @default.
• W2086081421 hasConcept C2908929049 @default.
• W2086081421 hasConcept C71924100 @default.
• W2086081421 hasConcept C84393581 @default.
• W2086081421 hasConceptScore W2086081421C126322002 @default.
• W2086081421 hasConceptScore W2086081421C134018914 @default.
• W2086081421 hasConceptScore W2086081421C138976137 @default.
• W2086081421 hasConceptScore W2086081421C142225936 @default.
• W2086081421 hasConceptScore W2086081421C159641895 @default.
• W2086081421 hasConceptScore W2086081421C185592680 @default.
• W2086081421 hasConceptScore W2086081421C198710026 @default.
• W2086081421 hasConceptScore W2086081421C2779721657 @default.
• W2086081421 hasConceptScore W2086081421C2779881121 @default.
• W2086081421 hasConceptScore W2086081421C2780091579 @default.
• W2086081421 hasConceptScore W2086081421C2780306776 @default.
• W2086081421 hasConceptScore W2086081421C2908929049 @default.

• next