FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086082022> ?p ?o ?g. }

• W2086082022 endingPage "13774" @default.
• W2086082022 startingPage "13765" @default.
• W2086082022 abstract "D-aspartate (D-Asp) is found in specific neurons, transported to neuronal terminals and released in a stimulation-dependent manner. Because D-Asp formation is not well understood, determining its function has proved challenging. Significant levels of D-Asp are present in the cerebral ganglion of the F- and C-clusters of the invertebrate Aplysia californica, and D-Asp appears to be involved in cell-cell communication in this system. Here, we describe a novel protein, DAR1, from A. californica that can convert aspartate and serine to their other chiral form in a pyridoxal 5'-phosphate (PLP)-dependent manner. DAR1 has a predicted length of 325 amino acids and is 55% identical to the bivalve aspartate racemase, EC 5.1.1.13, and 41% identical to the mammalian serine racemase, EC 5.1.1.18. However, it is only 14% identical to the recently reported mammalian aspartate racemase, DR, which is closely related to glutamate-oxaloacetate transaminase, EC 2.6.1.1. Using whole-mount immunohistochemistry staining of the A. californica central nervous system, we localized DAR1-like immunoreactivity to the medial region of the cerebral ganglion where the F- and C-clusters are situated. The biochemical and functional similarities between DAR1 and other animal serine and aspartate racemases make it valuable for examining PLP-dependent racemases, promising to increase our knowledge of enzyme regulation and ultimately, D-serine and D-Asp signaling pathways." @default.
• W2086082022 created "2016-06-24" @default.
• W2086082022 creator A5006238710 @default.
• W2086082022 creator A5051552869 @default.
• W2086082022 creator A5052787170 @default.
• W2086082022 creator A5091277382 @default.
• W2086082022 date "2011-04-01" @default.
• W2086082022 modified "2023-09-29" @default.
• W2086082022 title "A Novel Pyridoxal 5′-Phosphate-dependent Amino Acid Racemase in the Aplysia californica Central Nervous System" @default.
• W2086082022 cites W1560269696 @default.
• W2086082022 cites W1593023392 @default.
• W2086082022 cites W1604887751 @default.
• W2086082022 cites W1840861722 @default.
• W2086082022 cites W1932353425 @default.
• W2086082022 cites W1968294697 @default.
• W2086082022 cites W1976159577 @default.
• W2086082022 cites W1980347624 @default.
• W2086082022 cites W1985332974 @default.
• W2086082022 cites W1987923616 @default.
• W2086082022 cites W1993322714 @default.
• W2086082022 cites W1994412066 @default.
• W2086082022 cites W2004471733 @default.
• W2086082022 cites W2010762730 @default.
• W2086082022 cites W2025590235 @default.
• W2086082022 cites W2028225661 @default.
• W2086082022 cites W2038400418 @default.
• W2086082022 cites W2038719213 @default.
• W2086082022 cites W2046151253 @default.
• W2086082022 cites W2048181000 @default.
• W2086082022 cites W2049700857 @default.
• W2086082022 cites W2059342052 @default.
• W2086082022 cites W2059647024 @default.
• W2086082022 cites W2066430214 @default.
• W2086082022 cites W2069776963 @default.
• W2086082022 cites W2087940090 @default.
• W2086082022 cites W2088262338 @default.
• W2086082022 cites W2089933527 @default.
• W2086082022 cites W2092103545 @default.
• W2086082022 cites W2106836101 @default.
• W2086082022 cites W2109805561 @default.
• W2086082022 cites W2110269231 @default.
• W2086082022 cites W2124439293 @default.
• W2086082022 cites W2125269329 @default.
• W2086082022 cites W2140022167 @default.
• W2086082022 cites W2153173736 @default.
• W2086082022 cites W2167232166 @default.
• W2086082022 cites W4293527003 @default.
• W2086082022 cites W53777764 @default.
• W2086082022 doi "https://doi.org/10.1074/jbc.m110.178228" @default.
• W2086082022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3075720" @default.
• W2086082022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21343289" @default.
• W2086082022 hasPublicationYear "2011" @default.
• W2086082022 type Work @default.
• W2086082022 sameAs 2086082022 @default.
• W2086082022 citedByCount "32" @default.
• W2086082022 countsByYear W20860820222012 @default.
• W2086082022 countsByYear W20860820222013 @default.
• W2086082022 countsByYear W20860820222014 @default.
• W2086082022 countsByYear W20860820222015 @default.
• W2086082022 countsByYear W20860820222016 @default.
• W2086082022 countsByYear W20860820222017 @default.
• W2086082022 countsByYear W20860820222019 @default.
• W2086082022 countsByYear W20860820222020 @default.
• W2086082022 countsByYear W20860820222021 @default.
• W2086082022 countsByYear W20860820222022 @default.
• W2086082022 countsByYear W20860820222023 @default.
• W2086082022 crossrefType "journal-article" @default.
• W2086082022 hasAuthorship W2086082022A5006238710 @default.
• W2086082022 hasAuthorship W2086082022A5051552869 @default.
• W2086082022 hasAuthorship W2086082022A5052787170 @default.
• W2086082022 hasAuthorship W2086082022A5091277382 @default.
• W2086082022 hasBestOaLocation W20860820221 @default.
• W2086082022 hasConcept C169760540 @default.
• W2086082022 hasConcept C170493617 @default.
• W2086082022 hasConcept C181199279 @default.
• W2086082022 hasConcept C197957613 @default.
• W2086082022 hasConcept C2776414213 @default.
• W2086082022 hasConcept C2776834122 @default.
• W2086082022 hasConcept C2778178740 @default.
• W2086082022 hasConcept C2780859938 @default.
• W2086082022 hasConcept C515207424 @default.
• W2086082022 hasConcept C55493867 @default.
• W2086082022 hasConcept C61174792 @default.
• W2086082022 hasConcept C86803240 @default.
• W2086082022 hasConcept C95444343 @default.
• W2086082022 hasConceptScore W2086082022C169760540 @default.
• W2086082022 hasConceptScore W2086082022C170493617 @default.
• W2086082022 hasConceptScore W2086082022C181199279 @default.
• W2086082022 hasConceptScore W2086082022C197957613 @default.
• W2086082022 hasConceptScore W2086082022C2776414213 @default.
• W2086082022 hasConceptScore W2086082022C2776834122 @default.
• W2086082022 hasConceptScore W2086082022C2778178740 @default.
• W2086082022 hasConceptScore W2086082022C2780859938 @default.
• W2086082022 hasConceptScore W2086082022C515207424 @default.
• W2086082022 hasConceptScore W2086082022C55493867 @default.
• W2086082022 hasConceptScore W2086082022C61174792 @default.
• W2086082022 hasConceptScore W2086082022C86803240 @default.
• W2086082022 hasConceptScore W2086082022C95444343 @default.

• next