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- W2086087263 abstract "Casein kinase 1 delta (CK1δ) and its closest homologue CK1ε are key regulators of diverse cellular growth and survival processes such as Wnt signaling, DNA repair, and circadian rhythms. We report three crystal structures of the kinase domain of human CK1δ, one apo and two complexed with a potent and selective CK1δ/ε inhibitor PF670462 in two different crystal forms. These structures provide a molecular basis for the strong and specific inhibitor interactions and suggest clues for further development of CK1δ/ε inhibitors." @default.
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- W2086087263 date "2012-01-05" @default.
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- W2086087263 title "Structural Basis for the Interaction between Casein Kinase 1 Delta and a Potent and Selective Inhibitor" @default.
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- W2086087263 doi "https://doi.org/10.1021/jm201387s" @default.
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