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• W208608808 abstract "Background. Antibiotic resistant bacteria have been a source of ever-increasing therapeutic problem with profound health and socioeconomic pressures. Hence, continued surveillance for bacteria susceptibility pattern is useful to determine the existing and future challenges of effective therapy. Aim. This study was carried out to evaluate the resistance patterns of some community isolates of Staphylococcus aureus to some conventional antibiotics within a locality in southeastern Nigeria. Material and methods. Preliminary characterizations of the plasmid DNA were also carried out. Results. Here we show the results obtained, the resistances of the isolates to the antibiotics were recorded in the following order: Flucloxacillin > Cotrimoxazole > Cephalexin > Chloramphenicol > Tetracycline > Minocycline ~ Clindamycin > Gentamicin ~ Erythromycin > AmoxicillinClavulanic acid ~ Cloxacillin > Amoxicillin. The MIC results showed that the isolates were highly susceptible to Clindamycin but resistant to Tetracycline. Clindamycin was equally shown to exert a relatively higher bactericidal activity among five other antibiotics tested. Preliminary characterization of eight (8) isolated bacteria plasmids from eight resistant bacteria isolates gave mobilities (distances travelled) ranging from 3- 5 mm. These plasmids may be responsible for their observed high level of drug resistance. Early antibiotics susceptibility surveillance exercises therefore helps ascertain and generate a good framework for effective management and control of resistant and multiple-drug resistant strains." @default.
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• W208608808 date "2009-01-01" @default.
• W208608808 modified "2023-09-27" @default.
• W208608808 title "Antibiotic Resistance Patterns of Staphylococcus aureus Isolated from Nostrils of Healthy Human Subjects in a Southeastern Nigeria Locality" @default.
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