FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086091776> ?p ?o ?g. }

• W2086091776 endingPage "762" @default.
• W2086091776 startingPage "748" @default.
• W2086091776 abstract "Protein sequence, structure, and function are inherently linked through evolution and population genetics. Our knowledge of protein structure comes from solved structures in the Protein Data Bank (PDB), our knowledge of sequence through sequences found in the NCBI sequence databases (http://www.ncbi.nlm.nih.gov/), and our knowledge of function through a limited set of in-vitro biochemical studies. How these intersect through evolution is described in the first part of the review. In the second part, our understanding of a series of questions is addressed. This includes how sequences evolve within structures, how evolutionary processes enable structural transitions, how the folding process can change through evolution and what the fitness impacts of this might be. Moving beyond static structures, the evolution of protein kinetics (including normal modes) is discussed, as is the evolution of conformational ensembles and structurally disordered proteins. This ties back to a question of the role of neostructuralization and how it relates to selection on sequences for functions. The relationship between metastability, the fitness landscape, sequence divergence, and organismal effective population size is explored. Lastly, a brief discussion of modeling the evolution of sequences of ordered and disordered proteins is entertained." @default.
• W2086091776 created "2016-06-24" @default.
• W2086091776 creator A5017197636 @default.
• W2086091776 creator A5060905723 @default.
• W2086091776 creator A5075418921 @default.
• W2086091776 date "2011-10-28" @default.
• W2086091776 modified "2023-09-26" @default.
• W2086091776 title "The Evolution of Protein Structures and Structural Ensembles Under Functional Constraint" @default.
• W2086091776 cites W1482509850 @default.
• W2086091776 cites W1504837664 @default.
• W2086091776 cites W1517305271 @default.
• W2086091776 cites W1969836305 @default.
• W2086091776 cites W1969984696 @default.
• W2086091776 cites W1970040698 @default.
• W2086091776 cites W1971650367 @default.
• W2086091776 cites W1972595484 @default.
• W2086091776 cites W1973951655 @default.
• W2086091776 cites W1974105492 @default.
• W2086091776 cites W1975017420 @default.
• W2086091776 cites W1980885563 @default.
• W2086091776 cites W1987043156 @default.
• W2086091776 cites W1988625445 @default.
• W2086091776 cites W1989893963 @default.
• W2086091776 cites W1990428289 @default.
• W2086091776 cites W1990823383 @default.
• W2086091776 cites W1991906934 @default.
• W2086091776 cites W1992579032 @default.
• W2086091776 cites W1994267130 @default.
• W2086091776 cites W1998041471 @default.
• W2086091776 cites W2003695748 @default.
• W2086091776 cites W2003890287 @default.
• W2086091776 cites W2004384566 @default.
• W2086091776 cites W2004698009 @default.
• W2086091776 cites W2007268492 @default.
• W2086091776 cites W2011754703 @default.
• W2086091776 cites W2020739850 @default.
• W2086091776 cites W2027881855 @default.
• W2086091776 cites W2028599082 @default.
• W2086091776 cites W2030776726 @default.
• W2086091776 cites W2032675793 @default.
• W2086091776 cites W2033047894 @default.
• W2086091776 cites W2039790548 @default.
• W2086091776 cites W2040517336 @default.
• W2086091776 cites W2046535373 @default.
• W2086091776 cites W2052114961 @default.
• W2086091776 cites W2056825675 @default.
• W2086091776 cites W2058864686 @default.
• W2086091776 cites W2059001055 @default.
• W2086091776 cites W2060665868 @default.
• W2086091776 cites W2071988957 @default.
• W2086091776 cites W2075110982 @default.
• W2086091776 cites W2077745997 @default.
• W2086091776 cites W2077797834 @default.
• W2086091776 cites W2084887718 @default.
• W2086091776 cites W2089597488 @default.
• W2086091776 cites W2092006899 @default.
• W2086091776 cites W2092189458 @default.
• W2086091776 cites W2097270746 @default.
• W2086091776 cites W2099672241 @default.
• W2086091776 cites W2100022666 @default.
• W2086091776 cites W2101120426 @default.
• W2086091776 cites W2104549437 @default.
• W2086091776 cites W2106107652 @default.
• W2086091776 cites W2106243980 @default.
• W2086091776 cites W2110821410 @default.
• W2086091776 cites W2112792893 @default.
• W2086091776 cites W2117161143 @default.
• W2086091776 cites W2128653811 @default.
• W2086091776 cites W2129020329 @default.
• W2086091776 cites W2139348052 @default.
• W2086091776 cites W2144482528 @default.
• W2086091776 cites W2144729032 @default.
• W2086091776 cites W2146003432 @default.
• W2086091776 cites W2147650094 @default.
• W2086091776 cites W2150058447 @default.
• W2086091776 cites W2150842476 @default.
• W2086091776 cites W2153457180 @default.
• W2086091776 cites W2154414334 @default.
• W2086091776 cites W2158292347 @default.
• W2086091776 cites W2160426410 @default.
• W2086091776 cites W2160529747 @default.
• W2086091776 cites W2161199282 @default.
• W2086091776 cites W2161311439 @default.
• W2086091776 cites W2164447290 @default.
• W2086091776 cites W2165967770 @default.
• W2086091776 cites W2171381988 @default.
• W2086091776 cites W2171501215 @default.
• W2086091776 cites W4210623056 @default.
• W2086091776 doi "https://doi.org/10.3390/genes2040748" @default.
• W2086091776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3927589" @default.
• W2086091776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24710290" @default.
• W2086091776 hasPublicationYear "2011" @default.
• W2086091776 type Work @default.
• W2086091776 sameAs 2086091776 @default.
• W2086091776 citedByCount "49" @default.
• W2086091776 countsByYear W20860917762012 @default.
• W2086091776 countsByYear W20860917762013 @default.
• W2086091776 countsByYear W20860917762015 @default.

• next