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• W2086097600 endingPage "1996" @default.
• W2086097600 startingPage "1991" @default.
• W2086097600 abstract "The ability of a series of β-carboline compounds to inhibit monoamine oxidase (MAO) was studied in homogenates of mouse brain and liver. The in vitro structure-activity study with tryptamine as substrate showed the following to affect the degree of MAO inhibition: methyl group at carbon-1; methoxy or hydroxy group at carbon-6 or 7; ring saturation. In general, there was greater in vitro inhibition of brain MAO than of liver MAO. 6-Methoxy-1,2,3,4-tetrahydro-β-carboline produced greater MAO inhibition with serotonin as the substrate than with β-phenylethylamine both in vitro and in vivo, suggesting that it is a relatively selective inhibitor of MAO type A." @default.
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• W2086097600 date "1977-11-01" @default.
• W2086097600 modified "2023-10-14" @default.
• W2086097600 title "Monoamine oxidase inhibition in brain and liver produced by β-carbolines: structure-activity relationships and substrate specificity" @default.
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• W2086097600 doi "https://doi.org/10.1016/0006-2952(77)90007-7" @default.
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