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- W2086103634 abstract "Findings from the 18-year follow-up study of an initially healthy young group of men have been reviewed. During the interval from 24 years to 42 years of age significant changes were observed in weight, blood pressure, electrocardiograms and serum lipids. Blood pressures appeared to be a continuous variable influenced by multiple factors, as suggested by Pickering. A positive family history of vascular disease, excessive gain in weight, and a preponderance of mesomorphy and endomorphy were associated with greater increments in blood pressure and the presence of high blood pressure. The cold pressor test did not correlate with either final blood pressure or increment of blood pressure. Elevations in the very low density lipoproteins, which transport triglyceride, were found in those with a positive family history and with a gain in weight of over 10 pounds. Differences in somatotype were less significant determinants. Serial changes in electrocardiograms were reviewed. With increasing age there was a significant increase in the P-R interval, a decrease in the QRS amplitude (σQRS), and a leftward movement of the QRS vector orientation. No significant changes were noted in the wave form of the Q, R or S waves. Leftward shift of the QRS vector was associated with significantly greater gain in weight, higher lowdensity lipoprotein concentration, and greater increase in blood pressure. The relation of these clinical findings to the development of cardiovascular disease has been evaluated and discussed." @default.
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- W2086103634 date "1965-01-01" @default.
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- W2086103634 title "Determinants of cardiovascular disease in a young population" @default.
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- W2086103634 doi "https://doi.org/10.1016/0002-9149(65)90594-1" @default.
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