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• W2086119573 endingPage "3011" @default.
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• W2086119573 abstract "UV-A radiation (320-400 nm) induces damage to the DNA molecule and its components through different photosensitized reactions. Among these processes, photosensitized oxidations may occur through electron transfer or hydrogen abstraction (type I) and/or the production of singlet molecular oxygen ((1)O2) (type II). Pterins, heterocyclic compounds widespread in biological systems, participate in relevant biological processes and are able to act as photosensitizers. We have investigated the photosensitized oxidation of 2'-deoxyguanosine 5'-monophosphate (dGMP) by pterin (PT) in aqueous solution under UV-A irrradiation. Kinetic analysis was employed to evaluate the participation of both types of mechanism under different pH conditions. The rate constant of (1)O2 total quenching (k(t)) by dGMP was determined by steady-state analysis of the (1)O2 NIR luminescence, whereas the rate constant of the chemical reaction between (1)O2 and dGMP (k(r)) was evaluated from kinetic analysis of concentration profiles obtained by HPLC. The results show that the oxidation of dGMP photosensitized by PT occurs through two competing mechanisms that contribute in different proportions depending on the pH. The dominant mechanism in alkaline media involves the reaction of dGMP with (1)O2 produced by energy transfer from the PT triplet state to molecular oxygen (type II). In contrast, under acidic pH conditions, where PT and the guanine moiety of dGMP are not ionized, the main pathway for dGMP oxidation involves an initial electron transfer between dGMP and the PT triplet state (type I mechanism). The biological implications of the results obtained are also discussed." @default.
• W2086119573 created "2016-06-24" @default.
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• W2086119573 date "2008-02-16" @default.
• W2086119573 modified "2023-10-07" @default.
• W2086119573 title "Oxidation of 2‘-Deoxyguanosine 5‘-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism" @default.
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• W2086119573 doi "https://doi.org/10.1021/ja075367j" @default.
• W2086119573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18278909" @default.
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