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• W2086121036 abstract "Synthesis and structure–activity relationship (SAR) studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones, a novel class of calcium receptor antagonists is described with particular emphasis on optimization of the pharmacokinetic/pharmacodynamic parameters required for a short duration of action compound. Orally-active compounds were identified which displayed the desired animal pharmacology (rapid and transient stimulation of parathyroid hormone) essential for bone anabolic effects." @default.
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• W2086121036 date "2009-08-01" @default.
• W2086121036 modified "2023-10-16" @default.
• W2086121036 title "Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists" @default.
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• W2086121036 doi "https://doi.org/10.1016/j.bmcl.2009.07.004" @default.
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