FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086126521> ?p ?o ?g. }

• W2086126521 endingPage "13604" @default.
• W2086126521 startingPage "13598" @default.
• W2086126521 abstract "Lipid−water interaction plays an important role in the properties of lipid bilayers, cryoprotectants, and membrane-associated peptides and proteins. The temperature at which water bound to lipid bilayers freezes is lower than that of free water. Here, we report a solid-state NMR investigation on the freezing point depression of water in phospholipid bilayers in the presence and absence of cholesterol. Deuterium NMR spectra at different temperatures ranging from −75 to +10 °C were obtained from fully 2H2O-hydrated POPC (1-palmitoyl-2-oleoylphosphatidylcholine) multilamellar vesicles (MLVs), prepared with and without cholesterol, to determine the freezing temperature of water and the effect of cholesterol on the freezing temperature of water in POPC bilayers. Our 2H NMR experiments reveal the motional behavior of unfrozen water molecules in POPC bilayers even at temperatures significantly below 0 °C and show that the presence of cholesterol further lowered the freezing temperature of water in POPC bilayers. These results suggest that in the presence of cholesterol the fluidity and dynamics of lipid bilayers can be retained even at very low temperatures as exist in the liquid crystalline phase of the lipid. Therefore, bilayer samples prepared with a cryoprotectant like cholesterol should enable the performance of multidimensional solid-state NMR experiments to investigate the structure, dynamics, and topology of membrane proteins at a very low temperature with enhanced sample stability and possibly a better sensitivity. Phosphorus-31 NMR data suggest that lipid bilayers can be aligned at low temperatures, while 15N NMR experiments demonstrate that such aligned samples can be used to enhance the signal-to-noise ratio of 15N chemical shift spectra of a 37-residue human antimicrobial peptide, LL-37." @default.
• W2086126521 created "2016-06-24" @default.
• W2086126521 creator A5006414766 @default.
• W2086126521 creator A5069980594 @default.
• W2086126521 creator A5084832904 @default.
• W2086126521 date "2008-11-08" @default.
• W2086126521 modified "2023-10-17" @default.
• W2086126521 title "Freezing Point Depression of Water in Phospholipid Membranes: A Solid-State NMR Study" @default.
• W2086126521 cites W1529057880 @default.
• W2086126521 cites W1964832767 @default.
• W2086126521 cites W1967579525 @default.
• W2086126521 cites W1972361033 @default.
• W2086126521 cites W1972599904 @default.
• W2086126521 cites W1980478162 @default.
• W2086126521 cites W1988098903 @default.
• W2086126521 cites W1989197214 @default.
• W2086126521 cites W1990084499 @default.
• W2086126521 cites W1992915003 @default.
• W2086126521 cites W1993209190 @default.
• W2086126521 cites W1993682518 @default.
• W2086126521 cites W1993717608 @default.
• W2086126521 cites W1994609929 @default.
• W2086126521 cites W1995861782 @default.
• W2086126521 cites W1998212987 @default.
• W2086126521 cites W1999978597 @default.
• W2086126521 cites W2001088615 @default.
• W2086126521 cites W2005736398 @default.
• W2086126521 cites W2008747611 @default.
• W2086126521 cites W2009932900 @default.
• W2086126521 cites W2011577346 @default.
• W2086126521 cites W2015132445 @default.
• W2086126521 cites W2020154280 @default.
• W2086126521 cites W2021566521 @default.
• W2086126521 cites W2023166363 @default.
• W2086126521 cites W2027806260 @default.
• W2086126521 cites W2030956339 @default.
• W2086126521 cites W2032977115 @default.
• W2086126521 cites W2033575799 @default.
• W2086126521 cites W2038179254 @default.
• W2086126521 cites W2038371009 @default.
• W2086126521 cites W2038604236 @default.
• W2086126521 cites W2042645359 @default.
• W2086126521 cites W2043254463 @default.
• W2086126521 cites W2044451298 @default.
• W2086126521 cites W2048893291 @default.
• W2086126521 cites W2051190643 @default.
• W2086126521 cites W2051441143 @default.
• W2086126521 cites W2052583482 @default.
• W2086126521 cites W2054537071 @default.
• W2086126521 cites W2055659417 @default.
• W2086126521 cites W2056566990 @default.
• W2086126521 cites W2063116767 @default.
• W2086126521 cites W2064784820 @default.
• W2086126521 cites W2065137980 @default.
• W2086126521 cites W2065957033 @default.
• W2086126521 cites W2068205174 @default.
• W2086126521 cites W2068220342 @default.
• W2086126521 cites W2072655618 @default.
• W2086126521 cites W2073744272 @default.
• W2086126521 cites W2077051053 @default.
• W2086126521 cites W2080832034 @default.
• W2086126521 cites W2084797526 @default.
• W2086126521 cites W2099077346 @default.
• W2086126521 cites W2104258613 @default.
• W2086126521 cites W2107746113 @default.
• W2086126521 cites W2114526613 @default.
• W2086126521 cites W2127616123 @default.
• W2086126521 cites W2129772562 @default.
• W2086126521 cites W2131244140 @default.
• W2086126521 cites W2136856225 @default.
• W2086126521 cites W2139135024 @default.
• W2086126521 cites W2144693623 @default.
• W2086126521 cites W2160341834 @default.
• W2086126521 cites W2161767994 @default.
• W2086126521 cites W2338222880 @default.
• W2086126521 cites W2464133859 @default.
• W2086126521 cites W2466569098 @default.
• W2086126521 cites W2949551892 @default.
• W2086126521 doi "https://doi.org/10.1021/la8023698" @default.
• W2086126521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2649677" @default.
• W2086126521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18991419" @default.
• W2086126521 hasPublicationYear "2008" @default.
• W2086126521 type Work @default.
• W2086126521 sameAs 2086126521 @default.
• W2086126521 citedByCount "30" @default.
• W2086126521 countsByYear W20861265212012 @default.
• W2086126521 countsByYear W20861265212014 @default.
• W2086126521 countsByYear W20861265212015 @default.
• W2086126521 countsByYear W20861265212016 @default.
• W2086126521 countsByYear W20861265212017 @default.
• W2086126521 countsByYear W20861265212018 @default.
• W2086126521 countsByYear W20861265212019 @default.
• W2086126521 countsByYear W20861265212020 @default.
• W2086126521 countsByYear W20861265212021 @default.
• W2086126521 countsByYear W20861265212022 @default.
• W2086126521 countsByYear W20861265212023 @default.
• W2086126521 crossrefType "journal-article" @default.
• W2086126521 hasAuthorship W2086126521A5006414766 @default.

• next