Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086127203> ?p ?o ?g. }
- W2086127203 endingPage "131" @default.
- W2086127203 startingPage "125" @default.
- W2086127203 abstract "The beta-thymosins are a family of <5kDa (MW), mostly acidic, proteins which were originally defined in the immune system. Recently, specific members of this family of cytoplasmic polypeptides, namely beta-4 and beta-10, were shown to bind monomeric G-actin both in vitro and in vivo. Whilst many aspects of programmed cell death or ‘apoptosis’ remain to be defined, the Ca2+Mg2+-dependent endonuclease, DNase I does feature in this process. Monomeric G-actin binds to and inhibits the DNA-degrading activity of DNase I. Given that the intracellular abundance of thymosins beta-4 and beta-10 is related to cell division and differentiation and that anticancer/morphogenic agents such as retinoic acid (RA) and cyclic AMP modulate expression of their respective genes, it is possible that these G-actin sequestering proteins play significant roles in apoptosis perhaps mediated via DNase I." @default.
- W2086127203 created "2016-06-24" @default.
- W2086127203 creator A5005908423 @default.
- W2086127203 date "1994-09-01" @default.
- W2086127203 modified "2023-10-02" @default.
- W2086127203 title "Molecular interactions between G-actin, DNase I and the beta-thymosins in apoptosis: a hypothesis" @default.
- W2086127203 cites W1485674429 @default.
- W2086127203 cites W1494983920 @default.
- W2086127203 cites W1499029873 @default.
- W2086127203 cites W1500101213 @default.
- W2086127203 cites W1501566065 @default.
- W2086127203 cites W1514575046 @default.
- W2086127203 cites W1517746878 @default.
- W2086127203 cites W1524473687 @default.
- W2086127203 cites W1532539996 @default.
- W2086127203 cites W1538805645 @default.
- W2086127203 cites W1550784552 @default.
- W2086127203 cites W1559184092 @default.
- W2086127203 cites W1572054014 @default.
- W2086127203 cites W1589415602 @default.
- W2086127203 cites W1595543747 @default.
- W2086127203 cites W1608453530 @default.
- W2086127203 cites W1622184364 @default.
- W2086127203 cites W1795265328 @default.
- W2086127203 cites W1832527043 @default.
- W2086127203 cites W1871462244 @default.
- W2086127203 cites W1961082018 @default.
- W2086127203 cites W1970629830 @default.
- W2086127203 cites W1972772800 @default.
- W2086127203 cites W1974695256 @default.
- W2086127203 cites W1974853601 @default.
- W2086127203 cites W1982133573 @default.
- W2086127203 cites W1998251573 @default.
- W2086127203 cites W2000646975 @default.
- W2086127203 cites W2001626838 @default.
- W2086127203 cites W2002110794 @default.
- W2086127203 cites W2005623596 @default.
- W2086127203 cites W2008911600 @default.
- W2086127203 cites W2009183980 @default.
- W2086127203 cites W2009603041 @default.
- W2086127203 cites W2011075445 @default.
- W2086127203 cites W2011275029 @default.
- W2086127203 cites W2012111613 @default.
- W2086127203 cites W2015037585 @default.
- W2086127203 cites W2017729786 @default.
- W2086127203 cites W2023357737 @default.
- W2086127203 cites W2026452824 @default.
- W2086127203 cites W2027601618 @default.
- W2086127203 cites W2030110600 @default.
- W2086127203 cites W2032592355 @default.
- W2086127203 cites W2035348228 @default.
- W2086127203 cites W2037342782 @default.
- W2086127203 cites W2039157457 @default.
- W2086127203 cites W2039314838 @default.
- W2086127203 cites W2039624173 @default.
- W2086127203 cites W2043066069 @default.
- W2086127203 cites W2049377259 @default.
- W2086127203 cites W2055802714 @default.
- W2086127203 cites W2055912425 @default.
- W2086127203 cites W2057257609 @default.
- W2086127203 cites W2057391801 @default.
- W2086127203 cites W2059666350 @default.
- W2086127203 cites W2059750057 @default.
- W2086127203 cites W2061768758 @default.
- W2086127203 cites W2063135487 @default.
- W2086127203 cites W2069521331 @default.
- W2086127203 cites W2070751657 @default.
- W2086127203 cites W2071063451 @default.
- W2086127203 cites W2074114480 @default.
- W2086127203 cites W2076015841 @default.
- W2086127203 cites W2078457332 @default.
- W2086127203 cites W2081948388 @default.
- W2086127203 cites W2084609653 @default.
- W2086127203 cites W2087803277 @default.
- W2086127203 cites W2094799975 @default.
- W2086127203 cites W2101462909 @default.
- W2086127203 cites W2135977869 @default.
- W2086127203 cites W2137582985 @default.
- W2086127203 cites W2140040046 @default.
- W2086127203 cites W2146346171 @default.
- W2086127203 cites W2147416879 @default.
- W2086127203 cites W2150462979 @default.
- W2086127203 cites W2322885756 @default.
- W2086127203 cites W2413825389 @default.
- W2086127203 cites W4230863206 @default.
- W2086127203 cites W4242479720 @default.
- W2086127203 cites W4250799811 @default.
- W2086127203 doi "https://doi.org/10.1016/0306-9877(94)90135-x" @default.
- W2086127203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7815961" @default.
- W2086127203 hasPublicationYear "1994" @default.
- W2086127203 type Work @default.
- W2086127203 sameAs 2086127203 @default.
- W2086127203 citedByCount "23" @default.
- W2086127203 countsByYear W20861272032012 @default.
- W2086127203 countsByYear W20861272032013 @default.
- W2086127203 countsByYear W20861272032016 @default.
- W2086127203 countsByYear W20861272032023 @default.
- W2086127203 crossrefType "journal-article" @default.