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- W2086133026 abstract "Abstract The yeast Saccharomyces marxianus (NRRL-Y-1550) was grown in a chemically defined medium in the presence of increasing concentrations of isonicotinic acid hydrazide (INH), 0.4 to 2.4 mg/ml. It was found that the NAD content and the dry weight of the cells decreased with increasing concentrations of INH. Similar results have been reported for Mycobacterium tuberculosis H37Ra. The growth inhibition of the yeast by INH was completely reversed by l -tryptophan. When the yeast grew in the presence of INH, but in the absence of l -tryptophan. two growth factors for Lactobacillus plantarum (ATCC 8014) were found in the culture medium. One of the growth factors has been identified as anthranilic acid while the other one was the N- D - glucosylamine derivative of anthranilic acid, shown to be an artifact of the isolation technique used. These results indicate that the primary mode of action of INH on yeast might be the inhibition of the biosynthesis of 1-(O-carboxyphenylamino)-l-deoxyribulose-5-phosphate." @default.
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- W2086133026 date "1978-01-01" @default.
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- W2086133026 title "Mode of action of isoniazid on yeast" @default.
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- W2086133026 doi "https://doi.org/10.1016/0006-2952(78)90443-4" @default.
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