FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086134300> ?p ?o ?g. }

• W2086134300 abstract "Data sources for MS research are numerous but rarely provide an objective measure of drug therapy compliance coupled with patient-reported health outcomes. The objective of this paper is to describe the methods and baseline characteristics of the Therapy Optimization in MS (TOP MS) study designed to investigate the relationship between disease-modifying therapy compliance and health outcomes. TOP MS was designed as a prospective, observational, nationwide patient-focused study using an internet portal for data entry. The protocol was reviewed and approved by Sterling IRB. The study was registered with ClinicalTrials.gov. It captured structured survey data monthly from MS patients recruited by specialty pharmacies. Data collection included the clinical characteristics of MS such as MS relapses. Disability, quality of life and work productivity and activity impairment were assessed quarterly with well-validated scales. When events like severe fatigue or new or worsening depression were reported, feedback was provided to treating physicians. The therapy compliance measure was derived from pharmacy drug shipment records uploaded to the study database. The data presented in this paper use descriptive statistics. The TOP MS Study enrolled 2966 participants receiving their disease-modifying therapy (DMT) from specialty pharmacies. The mean age of the sample was 49 years, 80.4% were female, 89.9% were Caucasian and 55.7% were employed full or part time. Mean time since first symptoms was 11.5 years; mean duration since diagnosis was 9.5 years. Patient-reported EDSS was 3.5; 72.2% had a relapsing-remitting disease course. The most commonly reported symptoms at the time of enrollment were fatigue (74.7%), impaired coordination or balance (61.8%) and numbness and tingling (61.2%). Half of the sample was using glatiramer acetate and half was using beta-interferons. Demographic and clinical characteristics of the TOP MS sample at enrollment are consistent with other community-based MS samples, and the sample appears to be representative of DMT users in the US. TOP MS data can be used to explore the associations between disease-modifying therapy compliance and health outcomes. ClinicalTrials.gov ( NCT00819000 )" @default.
• W2086134300 created "2016-06-24" @default.
• W2086134300 creator A5000976216 @default.
• W2086134300 creator A5002705317 @default.
• W2086134300 creator A5002866949 @default.
• W2086134300 creator A5012376027 @default.
• W2086134300 creator A5015669455 @default.
• W2086134300 creator A5020449234 @default.
• W2086134300 creator A5067968646 @default.
• W2086134300 creator A5081126810 @default.
• W2086134300 date "2014-03-13" @default.
• W2086134300 modified "2023-10-14" @default.
• W2086134300 title "Therapy optimization in multiple sclerosis: a prospective observational study of therapy compliance and outcomes" @default.
• W2086134300 cites W1581887055 @default.
• W2086134300 cites W1946880690 @default.
• W2086134300 cites W1975970108 @default.
• W2086134300 cites W1978426087 @default.
• W2086134300 cites W1995819970 @default.
• W2086134300 cites W2004229234 @default.
• W2086134300 cites W2014094373 @default.
• W2086134300 cites W2038982872 @default.
• W2086134300 cites W2039541749 @default.
• W2086134300 cites W2045129699 @default.
• W2086134300 cites W2045947093 @default.
• W2086134300 cites W2057112394 @default.
• W2086134300 cites W2063780338 @default.
• W2086134300 cites W2084110857 @default.
• W2086134300 cites W2086325363 @default.
• W2086134300 cites W2114242035 @default.
• W2086134300 cites W2132322340 @default.
• W2086134300 cites W2139062201 @default.
• W2086134300 cites W2147300306 @default.
• W2086134300 cites W2147654413 @default.
• W2086134300 cites W2151144634 @default.
• W2086134300 cites W3347162 @default.
• W2086134300 cites W33609267 @default.
• W2086134300 doi "https://doi.org/10.1186/1471-2377-14-49" @default.
• W2086134300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3984676" @default.
• W2086134300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24624979" @default.
• W2086134300 hasPublicationYear "2014" @default.
• W2086134300 type Work @default.
• W2086134300 sameAs 2086134300 @default.
• W2086134300 citedByCount "10" @default.
• W2086134300 countsByYear W20861343002015 @default.
• W2086134300 countsByYear W20861343002016 @default.
• W2086134300 countsByYear W20861343002017 @default.
• W2086134300 countsByYear W20861343002018 @default.
• W2086134300 crossrefType "journal-article" @default.
• W2086134300 hasAuthorship W2086134300A5000976216 @default.
• W2086134300 hasAuthorship W2086134300A5002705317 @default.
• W2086134300 hasAuthorship W2086134300A5002866949 @default.
• W2086134300 hasAuthorship W2086134300A5012376027 @default.
• W2086134300 hasAuthorship W2086134300A5015669455 @default.
• W2086134300 hasAuthorship W2086134300A5020449234 @default.
• W2086134300 hasAuthorship W2086134300A5067968646 @default.
• W2086134300 hasAuthorship W2086134300A5081126810 @default.
• W2086134300 hasBestOaLocation W20861343001 @default.
• W2086134300 hasConcept C104863432 @default.
• W2086134300 hasConcept C126322002 @default.
• W2086134300 hasConcept C139719470 @default.
• W2086134300 hasConcept C159110408 @default.
• W2086134300 hasConcept C162324750 @default.
• W2086134300 hasConcept C1862650 @default.
• W2086134300 hasConcept C20387591 @default.
• W2086134300 hasConcept C23131810 @default.
• W2086134300 hasConcept C2776867660 @default.
• W2086134300 hasConcept C2779951463 @default.
• W2086134300 hasConcept C512399662 @default.
• W2086134300 hasConcept C71924100 @default.
• W2086134300 hasConceptScore W2086134300C104863432 @default.
• W2086134300 hasConceptScore W2086134300C126322002 @default.
• W2086134300 hasConceptScore W2086134300C139719470 @default.
• W2086134300 hasConceptScore W2086134300C159110408 @default.
• W2086134300 hasConceptScore W2086134300C162324750 @default.
• W2086134300 hasConceptScore W2086134300C1862650 @default.
• W2086134300 hasConceptScore W2086134300C20387591 @default.
• W2086134300 hasConceptScore W2086134300C23131810 @default.
• W2086134300 hasConceptScore W2086134300C2776867660 @default.
• W2086134300 hasConceptScore W2086134300C2779951463 @default.
• W2086134300 hasConceptScore W2086134300C512399662 @default.
• W2086134300 hasConceptScore W2086134300C71924100 @default.
• W2086134300 hasIssue "1" @default.
• W2086134300 hasLocation W20861343001 @default.
• W2086134300 hasLocation W20861343002 @default.
• W2086134300 hasLocation W20861343003 @default.
• W2086134300 hasLocation W20861343004 @default.
• W2086134300 hasLocation W20861343005 @default.
• W2086134300 hasOpenAccess W2086134300 @default.
• W2086134300 hasPrimaryLocation W20861343001 @default.
• W2086134300 hasRelatedWork W2000811477 @default.
• W2086134300 hasRelatedWork W2109147503 @default.
• W2086134300 hasRelatedWork W2349001406 @default.
• W2086134300 hasRelatedWork W2364829248 @default.
• W2086134300 hasRelatedWork W2365653098 @default.
• W2086134300 hasRelatedWork W2382841014 @default.
• W2086134300 hasRelatedWork W2385612156 @default.
• W2086134300 hasRelatedWork W3032220911 @default.
• W2086134300 hasRelatedWork W3045293259 @default.
• W2086134300 hasRelatedWork W4381328000 @default.
• W2086134300 hasVolume "14" @default.

• next