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- W2086136111 abstract "High potency adsorbates of methapyrilene, dextromethorphan, ephedrine, and pseudoephedrine were prepared by column procedures using a polymethacrylic acid ion-exchange resin. Taste evaluation of the adsorbates showed a significant reduction in bitterness of the drugs. Coating the adsorbate particles with a 4:1 ethylcellulose-hydroxypropylmethylcellulose mixture reduced the bitterness further. Taste coverage was maintained after incorporation of the coated adsorbate into chewable tablets. In vitro release-rate studies showed immediate and complete drug elution from uncoated adsorbates. Release from coated adsorbates varied with the extent of coating. In vivo drug availability was demonstrated by LD50 tests in mice and rats and by a urinary excretion crossover study in humans." @default.
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- W2086136111 date "1971-10-01" @default.
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- W2086136111 title "Polycarboxylic Acid Ion-Exchange Resin Adsorbates For Taste Coverage in Chewable Tablets" @default.
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- W2086136111 doi "https://doi.org/10.1002/jps.2600601018" @default.
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