Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086144654> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2086144654 endingPage "1411" @default.
- W2086144654 startingPage "1405" @default.
- W2086144654 abstract "Abstract The clinical features of myotonic dystrophy type 1 (DM1) and type 2 (DM2) may present striking similarity, whereas, in some cases, the DM2 phenotype may be so mild that the diagnosis may be missed. Therefore, the identification of disease‐specific histopathological patterns for DM1 and DM2 may help clinicians to correctly address genetic studies. We performed a comparative morphological and morphometric analysis on muscle biopsies from 10 DM1 and 11 DM2 patients, comparing type 1 and type 2 fibers as to: fiber type predominance, transverse diameter, atrophy and hypertrophy factors, and prevalence of central nuclei. In DM1 cases we observed preferential type 1 fiber atrophy and a higher prevalence of central nucleation among type 1 fibers in all cases. In DM2 muscle biopsies, high rates of atrophic and hypertrophic type 2 fibers were observed in most cases, and preferential central nucleation in type 2 fibers was present in all cases. As opposed to DM1, in which type 1 fibers display most of the histological changes, preferential atrophy and hypertrophy of type 2 fibers may be considered as markers of DM2. A higher prevalence of central nuclei among hypertrophic type 2 fibers has a predictive value for the diagnosis of DM2. Thus, morphometric and fiber type‐based histological analysis of muscle biopsies may help differentiate between DM1 and DM2 and guide molecular analysis. © 2008 Wiley Periodicals, Inc. Muscle Nerve, 2008" @default.
- W2086144654 created "2016-06-24" @default.
- W2086144654 creator A5009111661 @default.
- W2086144654 creator A5021429755 @default.
- W2086144654 creator A5034751093 @default.
- W2086144654 creator A5049960231 @default.
- W2086144654 creator A5063063427 @default.
- W2086144654 creator A5070176994 @default.
- W2086144654 creator A5071695158 @default.
- W2086144654 creator A5086375346 @default.
- W2086144654 creator A5089562370 @default.
- W2086144654 date "2008-09-24" @default.
- W2086144654 modified "2023-10-13" @default.
- W2086144654 title "Preferential central nucleation of type 2 myofibers is an invariable feature of myotonic dystrophy type 2" @default.
- W2086144654 cites W1979486745 @default.
- W2086144654 cites W1983463992 @default.
- W2086144654 cites W1994674028 @default.
- W2086144654 cites W2003636280 @default.
- W2086144654 cites W2004966001 @default.
- W2086144654 cites W2011071409 @default.
- W2086144654 cites W2068064099 @default.
- W2086144654 cites W2081219383 @default.
- W2086144654 cites W2084548137 @default.
- W2086144654 cites W2099643329 @default.
- W2086144654 cites W2102145465 @default.
- W2086144654 cites W2109406464 @default.
- W2086144654 cites W2109436341 @default.
- W2086144654 cites W2127487162 @default.
- W2086144654 cites W2130524159 @default.
- W2086144654 cites W2146894239 @default.
- W2086144654 cites W2332435050 @default.
- W2086144654 doi "https://doi.org/10.1002/mus.21122" @default.
- W2086144654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18816606" @default.
- W2086144654 hasPublicationYear "2008" @default.
- W2086144654 type Work @default.
- W2086144654 sameAs 2086144654 @default.
- W2086144654 citedByCount "50" @default.
- W2086144654 countsByYear W20861446542012 @default.
- W2086144654 countsByYear W20861446542013 @default.
- W2086144654 countsByYear W20861446542014 @default.
- W2086144654 countsByYear W20861446542015 @default.
- W2086144654 countsByYear W20861446542016 @default.
- W2086144654 countsByYear W20861446542017 @default.
- W2086144654 countsByYear W20861446542018 @default.
- W2086144654 countsByYear W20861446542019 @default.
- W2086144654 countsByYear W20861446542021 @default.
- W2086144654 countsByYear W20861446542022 @default.
- W2086144654 countsByYear W20861446542023 @default.
- W2086144654 crossrefType "journal-article" @default.
- W2086144654 hasAuthorship W2086144654A5009111661 @default.
- W2086144654 hasAuthorship W2086144654A5021429755 @default.
- W2086144654 hasAuthorship W2086144654A5034751093 @default.
- W2086144654 hasAuthorship W2086144654A5049960231 @default.
- W2086144654 hasAuthorship W2086144654A5063063427 @default.
- W2086144654 hasAuthorship W2086144654A5070176994 @default.
- W2086144654 hasAuthorship W2086144654A5071695158 @default.
- W2086144654 hasAuthorship W2086144654A5086375346 @default.
- W2086144654 hasAuthorship W2086144654A5089562370 @default.
- W2086144654 hasConcept C105702510 @default.
- W2086144654 hasConcept C126322002 @default.
- W2086144654 hasConcept C142724271 @default.
- W2086144654 hasConcept C167414201 @default.
- W2086144654 hasConcept C2778063965 @default.
- W2086144654 hasConcept C2780304057 @default.
- W2086144654 hasConcept C2781172350 @default.
- W2086144654 hasConcept C71924100 @default.
- W2086144654 hasConcept C86803240 @default.
- W2086144654 hasConceptScore W2086144654C105702510 @default.
- W2086144654 hasConceptScore W2086144654C126322002 @default.
- W2086144654 hasConceptScore W2086144654C142724271 @default.
- W2086144654 hasConceptScore W2086144654C167414201 @default.
- W2086144654 hasConceptScore W2086144654C2778063965 @default.
- W2086144654 hasConceptScore W2086144654C2780304057 @default.
- W2086144654 hasConceptScore W2086144654C2781172350 @default.
- W2086144654 hasConceptScore W2086144654C71924100 @default.
- W2086144654 hasConceptScore W2086144654C86803240 @default.
- W2086144654 hasIssue "5" @default.
- W2086144654 hasLocation W20861446541 @default.
- W2086144654 hasLocation W20861446542 @default.
- W2086144654 hasOpenAccess W2086144654 @default.
- W2086144654 hasPrimaryLocation W20861446541 @default.
- W2086144654 hasRelatedWork W1967748606 @default.
- W2086144654 hasRelatedWork W1977969758 @default.
- W2086144654 hasRelatedWork W2074852925 @default.
- W2086144654 hasRelatedWork W2159487497 @default.
- W2086144654 hasRelatedWork W2366018417 @default.
- W2086144654 hasRelatedWork W2391596537 @default.
- W2086144654 hasRelatedWork W2400838191 @default.
- W2086144654 hasRelatedWork W2415368541 @default.
- W2086144654 hasRelatedWork W3028871222 @default.
- W2086144654 hasRelatedWork W2523621469 @default.
- W2086144654 hasVolume "38" @default.
- W2086144654 isParatext "false" @default.
- W2086144654 isRetracted "false" @default.
- W2086144654 magId "2086144654" @default.
- W2086144654 workType "article" @default.