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• W2086150909 endingPage "e23893" @default.
• W2086150909 startingPage "e23893" @default.
• W2086150909 abstract "During embryonic development, there are numerous cases where organ or tissue formation depends upon the migration of primordial cells. In the Drosophila embryo, the visceral mesoderm (vm) acts as a substrate for the migration of several cell populations of epithelial origin, including the endoderm, the trachea and the salivary glands. These migratory processes require both integrins and laminins. The current model is that αPS1βPS (PS1) and/or αPS3βPS (PS3) integrins are required in migrating cells, whereas αPS2βPS (PS2) integrin is required in the vm, where it performs an as yet unidentified function. Here, we show that PS1 integrins are also required for the migration over the vm of cells of mesodermal origin, the caudal visceral mesoderm (CVM). These results support a model in which PS1 might have evolved to acquire the migratory function of integrins, irrespective of the origin of the tissue. This integrin function is highly specific and its specificity resides mainly in the extracellular domain. In addition, we have identified the Laminin α1,2 trimer, as the key extracellular matrix (ECM) component regulating CVM migration. Furthermore, we show that, as it is the case in vertebrates, integrins, and specifically PS2, contributes to CVM movement by participating in the correct assembly of the ECM that serves as tracks for migration." @default.
• W2086150909 created "2016-06-24" @default.
• W2086150909 creator A5004157437 @default.
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• W2086150909 creator A5021360242 @default.
• W2086150909 creator A5056658399 @default.
• W2086150909 date "2011-09-16" @default.
• W2086150909 modified "2023-10-13" @default.
• W2086150909 title "PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis" @default.
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• W2086150909 doi "https://doi.org/10.1371/journal.pone.0023893" @default.
• W2086150909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174947" @default.
• W2086150909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21949686" @default.
• W2086150909 hasPublicationYear "2011" @default.
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