Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086156714> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2086156714 abstract "The expression of thyroid hormones receptors in osteoblasts and osteoclasts has involved these cells as direct targets for triiodothyronine (T3), but thyroid hormones may also interact with other hormones or local growth factors to exert their actions on bone cells. Among these, growth hormone (GH) is recognised as participating in the acquisition and maintenance of bone mass and exerting stimulatory effects on human osteoblastic cells. The aim of this study was to investigate T3 effects on primary human adult osteoblast-like cells (HOB) as well as to test for possible interactions between T3 and GH on bone cell metabolism. Primary human bone cell cultures were obtained by outgrowth from trabecular bone fragments from the hip and knee. Dose-response studies demonstrated enhanced [3H]-thymidine incorporation for T3 at 10(-9), 10(-8), 10(-7) and 20(-7) M, with a maximal response of 162.81 +/- 12.97 % with T3 10(-8) M, compared to vehicle (p < 0.001). Time-course studies showed an increased osteoblast-like cell proliferation after 24 h, followed by a decrease of cell proliferation by 48 h and 72 h of culture, respectively, when compared to control cells, with a maximal response after 72 h (T3 10(-10) M: 45.21 +/- 6.97 %, p < 0.01). In addition, T3 markedly increased specific alkaline phosphatase (AP) activity in HOB (10(-10) M: 169.86 +/- 12.14 % vs. control, p < 0.001), but no significant influence on type I procollagen propeptide (PICP) production was observed. At 10(-9) - 10(-7) g/ml, GH significantly enhanced HOB proliferation (p < 0.001) however, GH effects were not dose-dependent. Triiodothyronine, at a high concentration (10(-7) M), stimulated GH-receptor (GHR) mRNA levels by 165.20 +/- 16.54 % after 24 h (p < 0.05). Correspondingly, a synergistic effect of T 3 with the same concentration and GH on cell proliferation in human adult osteoblast-like cells was found." @default.
- W2086156714 created "2016-06-24" @default.
- W2086156714 creator A5009109661 @default.
- W2086156714 creator A5022322945 @default.
- W2086156714 creator A5028618728 @default.
- W2086156714 creator A5044873349 @default.
- W2086156714 creator A5048572529 @default.
- W2086156714 creator A5082100709 @default.
- W2086156714 date "2003-05-14" @default.
- W2086156714 modified "2023-09-25" @default.
- W2086156714 title "The Effects of Triiodothyronine on Human Osteoblast-Like Cells Metabolism and Interactions with Growth Hormone" @default.
- W2086156714 doi "https://doi.org/10.1055/s-2003-39231" @default.
- W2086156714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12746755" @default.
- W2086156714 hasPublicationYear "2003" @default.
- W2086156714 type Work @default.
- W2086156714 sameAs 2086156714 @default.
- W2086156714 citedByCount "5" @default.
- W2086156714 countsByYear W20861567142012 @default.
- W2086156714 countsByYear W20861567142013 @default.
- W2086156714 countsByYear W20861567142015 @default.
- W2086156714 countsByYear W20861567142016 @default.
- W2086156714 crossrefType "journal-article" @default.
- W2086156714 hasAuthorship W2086156714A5009109661 @default.
- W2086156714 hasAuthorship W2086156714A5022322945 @default.
- W2086156714 hasAuthorship W2086156714A5028618728 @default.
- W2086156714 hasAuthorship W2086156714A5044873349 @default.
- W2086156714 hasAuthorship W2086156714A5048572529 @default.
- W2086156714 hasAuthorship W2086156714A5082100709 @default.
- W2086156714 hasConcept C126322002 @default.
- W2086156714 hasConcept C133605539 @default.
- W2086156714 hasConcept C134018914 @default.
- W2086156714 hasConcept C160160445 @default.
- W2086156714 hasConcept C170033053 @default.
- W2086156714 hasConcept C170493617 @default.
- W2086156714 hasConcept C181199279 @default.
- W2086156714 hasConcept C185592680 @default.
- W2086156714 hasConcept C202751555 @default.
- W2086156714 hasConcept C2778260815 @default.
- W2086156714 hasConcept C2778288131 @default.
- W2086156714 hasConcept C54355233 @default.
- W2086156714 hasConcept C55493867 @default.
- W2086156714 hasConcept C62112901 @default.
- W2086156714 hasConcept C71315377 @default.
- W2086156714 hasConcept C71924100 @default.
- W2086156714 hasConcept C81885089 @default.
- W2086156714 hasConcept C86803240 @default.
- W2086156714 hasConceptScore W2086156714C126322002 @default.
- W2086156714 hasConceptScore W2086156714C133605539 @default.
- W2086156714 hasConceptScore W2086156714C134018914 @default.
- W2086156714 hasConceptScore W2086156714C160160445 @default.
- W2086156714 hasConceptScore W2086156714C170033053 @default.
- W2086156714 hasConceptScore W2086156714C170493617 @default.
- W2086156714 hasConceptScore W2086156714C181199279 @default.
- W2086156714 hasConceptScore W2086156714C185592680 @default.
- W2086156714 hasConceptScore W2086156714C202751555 @default.
- W2086156714 hasConceptScore W2086156714C2778260815 @default.
- W2086156714 hasConceptScore W2086156714C2778288131 @default.
- W2086156714 hasConceptScore W2086156714C54355233 @default.
- W2086156714 hasConceptScore W2086156714C55493867 @default.
- W2086156714 hasConceptScore W2086156714C62112901 @default.
- W2086156714 hasConceptScore W2086156714C71315377 @default.
- W2086156714 hasConceptScore W2086156714C71924100 @default.
- W2086156714 hasConceptScore W2086156714C81885089 @default.
- W2086156714 hasConceptScore W2086156714C86803240 @default.
- W2086156714 hasLocation W20861567141 @default.
- W2086156714 hasLocation W20861567142 @default.
- W2086156714 hasOpenAccess W2086156714 @default.
- W2086156714 hasPrimaryLocation W20861567141 @default.
- W2086156714 hasRelatedWork W173270318 @default.
- W2086156714 hasRelatedWork W1985506888 @default.
- W2086156714 hasRelatedWork W2041345005 @default.
- W2086156714 hasRelatedWork W2067637914 @default.
- W2086156714 hasRelatedWork W2070480234 @default.
- W2086156714 hasRelatedWork W2118001750 @default.
- W2086156714 hasRelatedWork W2123776185 @default.
- W2086156714 hasRelatedWork W2159675791 @default.
- W2086156714 hasRelatedWork W305351029 @default.
- W2086156714 hasRelatedWork W4571987 @default.
- W2086156714 isParatext "false" @default.
- W2086156714 isRetracted "false" @default.
- W2086156714 magId "2086156714" @default.
- W2086156714 workType "article" @default.