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- W2086156968 endingPage "620" @default.
- W2086156968 startingPage "608" @default.
- W2086156968 abstract "Synaptic activity produces short-lived second messengers that ultimately yield a long-term depression (LTD) of cerebellar Purkinje cells. Here, we test the hypothesis that these brief second messenger signals are translated into long-lasting biochemical signals by a positive feedback loop that includes protein kinase C (PKC) and mitogen-activated protein kinase. Histochemical “epistasis” experiments demonstrate the reciprocal activation of these kinases, and physiological experiments—including the use of a light-activated protein kinase—demonstrate that such reciprocal activation is required for LTD. Timed application of enzyme inhibitors reveals that this positive feedback loop causes PKC to be active for more than 20 min, allowing sufficient time for LTD expression. Such regenerative mechanisms may sustain other long-lasting forms of synaptic plasticity and could be a general mechanism for prolonging signal transduction networks." @default.
- W2086156968 created "2016-06-24" @default.
- W2086156968 creator A5012778514 @default.
- W2086156968 creator A5048008812 @default.
- W2086156968 date "2008-08-01" @default.
- W2086156968 modified "2023-10-03" @default.
- W2086156968 title "A Positive Feedback Signal Transduction Loop Determines Timing of Cerebellar Long-Term Depression" @default.
- W2086156968 cites W1534319608 @default.
- W2086156968 cites W1570529068 @default.
- W2086156968 cites W1576671418 @default.
- W2086156968 cites W1585949905 @default.
- W2086156968 cites W1593803654 @default.
- W2086156968 cites W1858802571 @default.
- W2086156968 cites W1867794489 @default.
- W2086156968 cites W1919826524 @default.
- W2086156968 cites W1926511387 @default.
- W2086156968 cites W1957331510 @default.
- W2086156968 cites W1972392931 @default.
- W2086156968 cites W1974275159 @default.
- W2086156968 cites W1976949454 @default.
- W2086156968 cites W1979512764 @default.
- W2086156968 cites W1982058197 @default.
- W2086156968 cites W1984875486 @default.
- W2086156968 cites W1986155820 @default.
- W2086156968 cites W1988601767 @default.
- W2086156968 cites W1989480480 @default.
- W2086156968 cites W1990043673 @default.
- W2086156968 cites W1990501032 @default.
- W2086156968 cites W1990676315 @default.
- W2086156968 cites W1995680954 @default.
- W2086156968 cites W1997727729 @default.
- W2086156968 cites W1998274407 @default.
- W2086156968 cites W1998747207 @default.
- W2086156968 cites W1998880191 @default.
- W2086156968 cites W2000853989 @default.
- W2086156968 cites W2001895687 @default.
- W2086156968 cites W2004872546 @default.
- W2086156968 cites W2006851823 @default.
- W2086156968 cites W2006897764 @default.
- W2086156968 cites W2009225377 @default.
- W2086156968 cites W2009556803 @default.
- W2086156968 cites W2009823120 @default.
- W2086156968 cites W2012564759 @default.
- W2086156968 cites W2016717357 @default.
- W2086156968 cites W2017661675 @default.
- W2086156968 cites W2017726747 @default.
- W2086156968 cites W2017836075 @default.
- W2086156968 cites W2021235911 @default.
- W2086156968 cites W2021254337 @default.
- W2086156968 cites W2021547984 @default.
- W2086156968 cites W2023013885 @default.
- W2086156968 cites W2023447656 @default.
- W2086156968 cites W2026855344 @default.
- W2086156968 cites W2028992189 @default.
- W2086156968 cites W2035936653 @default.
- W2086156968 cites W2037235320 @default.
- W2086156968 cites W2038405912 @default.
- W2086156968 cites W2043390076 @default.
- W2086156968 cites W2050066016 @default.
- W2086156968 cites W2051827768 @default.
- W2086156968 cites W2051958752 @default.
- W2086156968 cites W2054128381 @default.
- W2086156968 cites W2054628503 @default.
- W2086156968 cites W2059800395 @default.
- W2086156968 cites W2068002594 @default.
- W2086156968 cites W2068502127 @default.
- W2086156968 cites W2072146699 @default.
- W2086156968 cites W2076740612 @default.
- W2086156968 cites W2077758457 @default.
- W2086156968 cites W2078647142 @default.
- W2086156968 cites W2079611342 @default.
- W2086156968 cites W2081299044 @default.
- W2086156968 cites W2081732444 @default.
- W2086156968 cites W2082431284 @default.
- W2086156968 cites W2084133226 @default.
- W2086156968 cites W2085580985 @default.
- W2086156968 cites W2086262311 @default.
- W2086156968 cites W2089185822 @default.
- W2086156968 cites W2091673674 @default.
- W2086156968 cites W2095936881 @default.
- W2086156968 cites W2096652014 @default.
- W2086156968 cites W2100688704 @default.
- W2086156968 cites W2100766258 @default.
- W2086156968 cites W2105069656 @default.
- W2086156968 cites W2106389606 @default.
- W2086156968 cites W2112927743 @default.
- W2086156968 cites W2115873388 @default.
- W2086156968 cites W2117029515 @default.
- W2086156968 cites W2119101729 @default.
- W2086156968 cites W2131856835 @default.
- W2086156968 cites W2133046879 @default.
- W2086156968 cites W2133667940 @default.
- W2086156968 cites W2135039550 @default.
- W2086156968 cites W2138141709 @default.
- W2086156968 cites W2141665272 @default.
- W2086156968 cites W2143471960 @default.
- W2086156968 cites W2145936933 @default.
- W2086156968 cites W2146388445 @default.