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- W2086158084 abstract "How to obtain an optimal efficiency of plasma exchanges in the treatment of severe hyperthryroidism has not been defined. In order to evaluate how long the exchanges must be continued to be fully effective in extracting thyroid hormones, we evaluated the extraction rate by repeated plasma sampling in two hyperthyroid patients and three euthyroid subjects who underwent a total of seven exchanges. Plasma concentrations of thyroid hormones were also determined just before, just after, and 24 hours following the exchange. The hormonal removal rate did not fall dramatically during the exchange, so that its efficiency — in terms of hormone extraction — depends closely on its duration. The determination of plasma thyroid hormone concentrations after the exchange does not appear to be useful in evaluating the thyroid hormone loss since these concentrations may not change in spite of the hormonal extraction. thyroid hormone / hyperthyroidism / plasma exchange Extraction des hormones thyroïdiennes par plasmaphérèse: étude du taux d'extraction. Le traitement des hyperthyroïdies graves par échange plasmatique nécessite encore actuellement une optimisation de la procédure. Nous avons évalué les seuils d'extraction et la durée des échanges chez deux patients hyperthyroïdiens et trois sujets euthyroïdiens. Les concentrations plasmatiques en hormones thyroïdiennes ont été également déterminées juste avant, aussitôt après et 24 h après les échanges. Le taux d'extraction d'hormone circulante ne diminue pas de façon très importante au cours de l'échange. C'est pourquoi en termes d'efficacité d'extraction hormonale, celle-ci dépend principalement de la durée des échanges plasmatiques. La mesure systématique des taux d'hormones thyroïdiennes circulantes après les échanges n'apparaît plus nécessaire pour déterminer le taux d'hormones extraites. hormones thyroïdiennes / hyperthyroïdisme l échange plasmatique" @default.
- W2086158084 created "2016-06-24" @default.
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- W2086158084 date "1992-01-01" @default.
- W2086158084 modified "2023-09-25" @default.
- W2086158084 title "Thyroid hormone extraction by plasma exchange: a study of extraction rate" @default.
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- W2086158084 doi "https://doi.org/10.1016/0753-3322(92)90046-a" @default.
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