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• W2086177789 startingPage "51" @default.
• W2086177789 abstract "Statins are potent inhibitors of cholesterol biosynthesis and have been used for the reduction of serum cholesterol levels to prevent cardiovascular diseases according to the cholesterol hypothesis of atherosclerosis. However, a wide varieties of beneficial of statins are known to rather actually occur earlier than serum cholesterol goes down, indicating cholesterol-independent effects. The beyond cholesterol lowering are socalled effects of statins, including eNOS expression, anti-oxidative function, anti-inflammatory action, osteomorphogenesis and so on. In addition to those, the of statins against carcinogenesis and degenerative processes in the brain leading to Alzheimer's disease and Parkinson's disease are examined in the literature.The pleiotropic of statins observed so far might be the reverse of a coin, where serious impairments of physiological functions of the intermediates of cholesterol biosynthesis take place. Adverse may happen to be manifested in the course of long-term use of statins. Considering the not much size of the benefits, statins should not be given to a large population to avoid terrible side-effects or demerits. Statin use may rather be better to be confined to patients with familial hypercholesterolemia who definitely obtain merits." @default.
• W2086177789 created "2016-06-24" @default.
• W2086177789 creator A5036731453 @default.
• W2086177789 date "2009-01-01" @default.
• W2086177789 modified "2023-09-24" @default.
• W2086177789 title "Pleiotropic effects of hypocholesterolemic drug statin" @default.
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• W2086177789 doi "https://doi.org/10.4010/jln.18.51" @default.
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