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- W2086192791 abstract "We recently reported artemisinin-resistant, uncomplicated Plasmodium falciparum malaria in Pursat, western Cambodia.1 Artemisinin resistance manifests as a slow parasite clearance rate (ie, a long parasite clearance half-life). A concern is that parasite clearance rates might be slower in patients with severe malaria2 who receive artemisinin monotherapy parenterally3 until they can take an artemisinin-based drug combination orally. To investigate this possibility, in 2010 we assessed parasite clearance in 30 patients with severe malaria in Pursat, with use of a protocol (ClinicalTrials.gov identifier: {type:clinical-trial,attrs:{text:NCT00341003,term_id:NCT00341003}}NCT00341003) approved by Cambodia’s National Ethics Committee for Health Research and the National Institute for Allergy and Infectious Diseases Institutional Review Board. Adults or parents of child participants gave written informed consent." @default.
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- W2086192791 date "2013-02-01" @default.
- W2086192791 modified "2023-09-24" @default.
- W2086192791 title "Slow parasite clearance rates in response to artemether in patients with severe malaria" @default.
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- W2086192791 doi "https://doi.org/10.1016/s1473-3099(12)70347-x" @default.
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