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• W2086200064 abstract "The asymmetric Nodal signaling cascade as a prerequisite for asymmetric body plan specification is conserved among deuterostomes. In this review we argue that symmetry breakage by cilia-driven leftward flow presents an ancestral character of vertebrates, likely the chordate phylum and maybe all deuterostomes. In vertebrates, leftward flow occurs in a transient structure, a monociliated epithelium, which is derived from superficial mesoderm and localizes to the archenteron roof during gastrulation. The chick as an example for the highly derived birds lacks superficial mesoderm and flow. This loss should be secondary, as flow is present from fish and amphibians to mammals." @default.
• W2086200064 created "2016-06-24" @default.
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• W2086200064 date "2009-06-01" @default.
• W2086200064 modified "2023-10-03" @default.
• W2086200064 title "Evolution of leftward flow" @default.
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• W2086200064 doi "https://doi.org/10.1016/j.semcdb.2008.11.005" @default.
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