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• W2086219095 startingPage "1180" @default.
• W2086219095 abstract "DNA primase synthesizes short RNA primers that replicative polymerases further elongate in order to initiate the synthesis of all new DNA strands. Thus, primase owes its existence to the inability of DNA polymerases to initiate DNA synthesis starting with 2 dNTPs. Here, we discuss the evolutionary relationships between the different families of primases (viral, eubacterial, archael, and eukaryotic) and the catalytic mechanisms of these enzymes. This includes how they choose an initiation site, elongate the growing primer, and then only synthesize primers of defined length via an inherent ability to count. Finally, the low fidelity of primases along with the development of primase inhibitors is described." @default.
• W2086219095 created "2016-06-24" @default.
• W2086219095 creator A5031137637 @default.
• W2086219095 creator A5056457744 @default.
• W2086219095 date "2010-05-01" @default.
• W2086219095 modified "2023-09-25" @default.
• W2086219095 title "Mechanism and evolution of DNA primases" @default.
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• W2086219095 doi "https://doi.org/10.1016/j.bbapap.2009.06.011" @default.
• W2086219095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846230" @default.

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