Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086222106> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2086222106 endingPage "236" @default.
- W2086222106 startingPage "231" @default.
- W2086222106 abstract "Background The aim of this study was to elucidate a possible role for vasoactive intestinal peptide (VIP) in the regulation of coronary vascular tone. Its action and the distribution of [125I]-VIP binding sites were examined in isolated human coronary arteries. Methods A total of 97 segments were obtained from 23 patients undergoing cardiac transplantation. Results VIP (10−10 to 3 × 10−7 M) relaxed preconstricted coronary segments in a concentration-dependent manner, with a maximum response of 73.8% ± 8.5% of the maximum relaxation induced by 1 μg/mL of nitroglycerin. This action was inhibited by the specific receptor antagonist [4CI-D-Phe6, Leu17] VIP, with a reduction of the maximum effect from 73.8% ± 8.5% to 38.9% ± 5.4% (P < 0.001). Prior exposure to atropine and indomethacin, and removal of the endothelium had no effect on responses to VIP. Receptor autoradiography demonstrated that [125I]-VIP binding sites were displaced by unlabeled peptide and by [4CI-D-Phe6, Leu17] VIP in a concentration-dependent manner, with 50% inhibitory concentration values of 1.35 × 10−8 and 2.41 × 10−8 M, respectively. The binding was predominantly associated with smooth muscle and perivascular regions, with no binding to the endothelial cells. Conclusions Our results indicate that VIP elicits vasodilatation of the human coronary artery by acting mainly on specific receptors presumably present on the smooth muscle. This peptidergic control mechanism may play a role in the regulation of coronary artery tone." @default.
- W2086222106 created "2016-06-24" @default.
- W2086222106 creator A5011158638 @default.
- W2086222106 creator A5047741410 @default.
- W2086222106 creator A5060235077 @default.
- W2086222106 creator A5072717487 @default.
- W2086222106 creator A5077915447 @default.
- W2086222106 creator A5083945230 @default.
- W2086222106 date "1992-03-01" @default.
- W2086222106 modified "2023-10-18" @default.
- W2086222106 title "Effect of vasoactive intestinal peptide and the distribution of receptors in human epicardial coronary arteries" @default.
- W2086222106 doi "https://doi.org/10.1097/00019501-199203000-00010" @default.
- W2086222106 hasPublicationYear "1992" @default.
- W2086222106 type Work @default.
- W2086222106 sameAs 2086222106 @default.
- W2086222106 citedByCount "4" @default.
- W2086222106 countsByYear W20862221062023 @default.
- W2086222106 crossrefType "journal-article" @default.
- W2086222106 hasAuthorship W2086222106A5011158638 @default.
- W2086222106 hasAuthorship W2086222106A5047741410 @default.
- W2086222106 hasAuthorship W2086222106A5060235077 @default.
- W2086222106 hasAuthorship W2086222106A5072717487 @default.
- W2086222106 hasAuthorship W2086222106A5077915447 @default.
- W2086222106 hasAuthorship W2086222106A5083945230 @default.
- W2086222106 hasConcept C118303440 @default.
- W2086222106 hasConcept C120770815 @default.
- W2086222106 hasConcept C126322002 @default.
- W2086222106 hasConcept C134018914 @default.
- W2086222106 hasConcept C164705383 @default.
- W2086222106 hasConcept C170493617 @default.
- W2086222106 hasConcept C2776820930 @default.
- W2086222106 hasConcept C2776992346 @default.
- W2086222106 hasConcept C2778742706 @default.
- W2086222106 hasConcept C2779395532 @default.
- W2086222106 hasConcept C2992686903 @default.
- W2086222106 hasConcept C71924100 @default.
- W2086222106 hasConcept C8330315 @default.
- W2086222106 hasConceptScore W2086222106C118303440 @default.
- W2086222106 hasConceptScore W2086222106C120770815 @default.
- W2086222106 hasConceptScore W2086222106C126322002 @default.
- W2086222106 hasConceptScore W2086222106C134018914 @default.
- W2086222106 hasConceptScore W2086222106C164705383 @default.
- W2086222106 hasConceptScore W2086222106C170493617 @default.
- W2086222106 hasConceptScore W2086222106C2776820930 @default.
- W2086222106 hasConceptScore W2086222106C2776992346 @default.
- W2086222106 hasConceptScore W2086222106C2778742706 @default.
- W2086222106 hasConceptScore W2086222106C2779395532 @default.
- W2086222106 hasConceptScore W2086222106C2992686903 @default.
- W2086222106 hasConceptScore W2086222106C71924100 @default.
- W2086222106 hasConceptScore W2086222106C8330315 @default.
- W2086222106 hasIssue "3" @default.
- W2086222106 hasLocation W20862221061 @default.
- W2086222106 hasOpenAccess W2086222106 @default.
- W2086222106 hasPrimaryLocation W20862221061 @default.
- W2086222106 hasRelatedWork W1966638871 @default.
- W2086222106 hasRelatedWork W1995680439 @default.
- W2086222106 hasRelatedWork W2003450342 @default.
- W2086222106 hasRelatedWork W2016408069 @default.
- W2086222106 hasRelatedWork W2016899150 @default.
- W2086222106 hasRelatedWork W2027568289 @default.
- W2086222106 hasRelatedWork W2030613578 @default.
- W2086222106 hasRelatedWork W2084109973 @default.
- W2086222106 hasRelatedWork W2132497793 @default.
- W2086222106 hasRelatedWork W2889454286 @default.
- W2086222106 hasVolume "3" @default.
- W2086222106 isParatext "false" @default.
- W2086222106 isRetracted "false" @default.
- W2086222106 magId "2086222106" @default.
- W2086222106 workType "article" @default.