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• W2086225807 abstract "The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of triclosan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery." @default.
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• W2086225807 date "2013-06-01" @default.
• W2086225807 modified "2023-10-16" @default.
• W2086225807 title "Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides" @default.
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• W2086225807 doi "https://doi.org/10.1016/j.bmcl.2013.04.035" @default.
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