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• W2086241510 endingPage "271" @default.
• W2086241510 startingPage "259" @default.
• W2086241510 abstract "Setting: The interaction of tubercle bacilli with macrophages is central to understanding of tuberculosis disease. Objective: The objective was to determine whether prior passage within macrophages affects the behavior of Mycobacterium tuberculosis (Mtb) upon re-entry into other macrophages. Design: Transmission electron microscopy was used to monitor fusion of bacterial phagosomes with late endosomal/lysosomal compartments using thoria as a fluid phase marker. Two-dimensional polyacrylamide gel electrophoresis was used to study bacterial protein expression within macrophages. Results: H37Rv and BCG expressed novel proteins within macrophages. H37Rv also underwent less fusion after intracellular (IC) (24.2±7.7%) than extracellular (XC) (67.4±5.5%) passage when the bacteria entered new macrophages in small clusters. These effects were inhibited by serum, and were not observed with H37Ra or BCG bacteria (78.9±1.6% fused for all conditions). In addition, vacuoles which contained single bacilli were less likely to acquire markers (26.9±2.6%) than those that contained multiple bacilli (77.3±2.8%). Conclusion: These results indicate that phagolysosomal fusion patterns can be modulated by a variety of factors and that virulent Mtb bacteria may express proteins within macrophages that alter their interaction with these host cells." @default.
• W2086241510 created "2016-06-24" @default.
• W2086241510 creator A5001688784 @default.
• W2086241510 creator A5040247985 @default.
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• W2086241510 date "2000-12-01" @default.
• W2086241510 modified "2023-10-15" @default.
• W2086241510 title "Intracellular passage within macrophages affects the trafficking of virulent tubercle bacilli upon reinfection of other macrophages in a serum-dependent manner" @default.
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• W2086241510 doi "https://doi.org/10.1054/tuld.2000.0268" @default.
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