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• W2086241566 endingPage "e1003441" @default.
• W2086241566 startingPage "e1003441" @default.
• W2086241566 abstract "Studying SIV infection of natural host monkey species, such as sooty mangabeys, has provided insights into the immune changes associated with these nonprogressive infections. Mangabeys maintain immune health despite high viremia or the dramatic CD4 T cell depletion that can occur following multitropic SIV infection. Here we evaluate double-negative (DN)(CD3+CD4-CD8-) T cells that are resistant to SIV infection due to a lack of CD4 surface expression, for their potential to fulfill a role as helper T cells. We first determined that DN T cells are polyclonal and predominantly exhibit an effector memory phenotype (CD95+CD62L-). Microarray analysis of TCR (anti-CD3/CD28) stimulated DN T cells indicated that these cells are multifunctional and upregulate genes with marked similarity to CD4 T cells, such as immune genes associated with Th1 (IFNγ), Th2 (IL4, IL5, IL13, CD40L), Th17 (IL17, IL22) and TFH (IL21, ICOS, IL6) function, chemokines such as CXCL9 and CXCL10 and transcription factors known to be actively regulated in CD4 T cells. Multifunctional T-helper cell responses were maintained in DN T cells from uninfected and SIV infected mangabeys and persisted in mangabeys exhibiting SIV mediated CD4 loss. Interestingly, TCR stimulation of DN T cells from SIV infected mangabeys results in a decreased upregulation of IFNγ and increased IL5 and IL13 expression compared to uninfected mangabeys. Evaluation of proliferative capacity of DN T cells in vivo (BrDU labeling) indicated that these cells maintain their ability to proliferate despite SIV infection, and express the homeostatic cytokine receptors CD25 (IL2 receptor) and CD127 (IL7 receptor). This study identifies the potential for a CD4-negative T cell subset that is refractory to SIV infection to perform T-helper functions in mangabeys and suggests that immune therapeutics designed to increase DN T cell function during HIV infection may have beneficial effects for the host immune system." @default.
• W2086241566 created "2016-06-24" @default.
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• W2086241566 date "2013-06-27" @default.
• W2086241566 modified "2023-09-24" @default.
• W2086241566 title "Multifunctional Double-negative T Cells in Sooty Mangabeys Mediate T-helper Functions Irrespective of SIV Infection" @default.
• W2086241566 cites W150683224 @default.
• W2086241566 cites W1541044354 @default.
• W2086241566 cites W1559378051 @default.
• W2086241566 cites W1914813822 @default.
• W2086241566 cites W1964052073 @default.
• W2086241566 cites W1965207154 @default.
• W2086241566 cites W1966242058 @default.
• W2086241566 cites W1970729674 @default.
• W2086241566 cites W1972897861 @default.
• W2086241566 cites W1973023339 @default.
• W2086241566 cites W1976882223 @default.
• W2086241566 cites W1981480494 @default.
• W2086241566 cites W1985784674 @default.
• W2086241566 cites W1990668812 @default.
• W2086241566 cites W1992872742 @default.
• W2086241566 cites W1993386412 @default.
• W2086241566 cites W1994287107 @default.
• W2086241566 cites W1999900107 @default.
• W2086241566 cites W2003121559 @default.
• W2086241566 cites W2004045952 @default.
• W2086241566 cites W2004186675 @default.
• W2086241566 cites W2008994596 @default.
• W2086241566 cites W2012419453 @default.
• W2086241566 cites W2012646581 @default.
• W2086241566 cites W2016488838 @default.
• W2086241566 cites W2020540857 @default.
• W2086241566 cites W2021530971 @default.
• W2086241566 cites W2024177594 @default.
• W2086241566 cites W2025373690 @default.
• W2086241566 cites W2025559962 @default.
• W2086241566 cites W2031283370 @default.
• W2086241566 cites W2035429778 @default.
• W2086241566 cites W2038797605 @default.
• W2086241566 cites W2051174680 @default.
• W2086241566 cites W2054716809 @default.
• W2086241566 cites W2055421491 @default.
• W2086241566 cites W2067596009 @default.
• W2086241566 cites W2080601697 @default.
• W2086241566 cites W2080627154 @default.
• W2086241566 cites W2081097093 @default.
• W2086241566 cites W2082620735 @default.
• W2086241566 cites W2082871926 @default.
• W2086241566 cites W2082915440 @default.
• W2086241566 cites W2083556128 @default.
• W2086241566 cites W2093174818 @default.
• W2086241566 cites W2093339678 @default.
• W2086241566 cites W2098275062 @default.
• W2086241566 cites W2098999499 @default.
• W2086241566 cites W2102829908 @default.
• W2086241566 cites W2107066107 @default.
• W2086241566 cites W2108083850 @default.
• W2086241566 cites W2110457277 @default.
• W2086241566 cites W2111622854 @default.
• W2086241566 cites W2114723202 @default.
• W2086241566 cites W2122162466 @default.
• W2086241566 cites W2122683221 @default.
• W2086241566 cites W2127080319 @default.
• W2086241566 cites W2130423344 @default.
• W2086241566 cites W2132733806 @default.
• W2086241566 cites W2133465414 @default.
• W2086241566 cites W2135521893 @default.
• W2086241566 cites W2135813534 @default.
• W2086241566 cites W2146869675 @default.
• W2086241566 cites W2148262907 @default.
• W2086241566 cites W2151817796 @default.
• W2086241566 cites W2157444253 @default.
• W2086241566 cites W2158217645 @default.
• W2086241566 cites W2159958805 @default.
• W2086241566 cites W2160697532 @default.
• W2086241566 cites W2163221345 @default.
• W2086241566 cites W2163873210 @default.
• W2086241566 cites W2170119368 @default.
• W2086241566 cites W2172187744 @default.
• W2086241566 cites W284027589 @default.
• W2086241566 doi "https://doi.org/10.1371/journal.ppat.1003441" @default.
• W2086241566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3694849" @default.
• W2086241566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23825945" @default.
• W2086241566 hasPublicationYear "2013" @default.
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