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• W2086245019 abstract "Although the function of the cell surface protein stem cell antigen-1 (Sca-1) has not been identified, expression of this molecule is a characteristic of bone marrow-derived hematopoietic stem cell populations. Expression of Sca-1, however, is not restricted to hematopoietic tissue. By RT-PCR and Western analysis, we found that Sca-1 is expressed in the adult mouse lung. Sca-1 immunohistochemistry revealed a linear staining pattern on the endothelial surface of large and small pulmonary arteries and veins and alveolar capillaries. Expression of Sca-1 in the pulmonary endothelium was confirmed by dual fluorescent microscopy on lung sections and by fluorescence-activated cell sorting analysis of digested lung tissue; each of these methods showed colocalization with the endothelial marker platelet/endothelial cell adhesion molecule-1. In the kidney, Sca-1 expression was also noted in large vessels, but, in contrast to the lung, was not observed in capillaries. Overall, our data indicate that Sca-1 expression helps define the surface phenotype of endothelial cells throughout the pulmonary vasculature." @default.
• W2086245019 created "2016-06-24" @default.
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• W2086245019 date "2003-06-01" @default.
• W2086245019 modified "2023-10-17" @default.
• W2086245019 title "Stem cell antigen-1 expression in the pulmonary vascular endothelium" @default.
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• W2086245019 doi "https://doi.org/10.1152/ajplung.00415.2002" @default.
• W2086245019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12611818" @default.
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