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- W2086255441 abstract "The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes. Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites. Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P<0.05) were seen between the morphology of chondrocytes observed in optical and conventional histology. This study concludes that the LSCA is capable of illustrating the surface and sub-surface appearance of healthy and defect articular cartilage, thereby providing a non-destructive method for assessing cartilage condition in vivo. In this role the LSCA may find application in the investigation of cartilage pathologies or repair techniques." @default.
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- W2086255441 date "2004-12-01" @default.
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- W2086255441 title "QUANTIFICATION OF CHONDROCYTE MORPHOLOGY BY CONFOCAL ARTHROSCOPY" @default.
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- W2086255441 doi "https://doi.org/10.1142/s0218957704001314" @default.
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