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• W2086267296 abstract "Lymphoid enhancer factor 1 (LEF-1) and T cell factor 1 (TCF-1) are closely related transcription factors that are both expressed during murine T cell differentiation and that regulate the T cell receptor alpha (TCRalpha) enhancer in transfection assays. Targeted gene disruption of either the Tcf1 or Lef1 gene in mice did not affect TCRalpha gene expression and resulted in an incomplete defect or no defect in thymocyte differentiation. Here, we examine a potential redundancy of these transcription factors by analyzing double-mutant mice. In fetal thymic organ cultures from Lef1-/- Tcf1-/- mice, alpha/beta T cell differentiation is completely arrested at the immature CD8+ single-positive (CD8+ ISP) stage and is markedly impaired at an earlier stage. In addition, we find that sorted CD8+ ISP cells from Lef1-/- Tcf1-/- mice express TCRbeta but show a severely reduced level of TCRalpha gene transcription. Together, these data show that LEF-1 and TCF-1 are redundant in the regulation of T cell differentiation and gene expression." @default.
• W2086267296 created "2016-06-24" @default.
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• W2086267296 date "1998-01-01" @default.
• W2086267296 modified "2023-10-13" @default.
• W2086267296 title "Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1" @default.
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• W2086267296 doi "https://doi.org/10.1016/s1074-7613(00)80454-9" @default.
• W2086267296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9462507" @default.
• W2086267296 hasPublicationYear "1998" @default.
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