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• W2086267846 abstract "To explore testicular factors which determine steroidogenesis, circulating and intratesticular steroid levels were measured and in vitro steroidogenesis in testicular minces and microsomes was investigated using adult rhesus monkeys before and after treatment with pharmacological doses of hCG or hCG together with hMG. After gonadotropin treatment serum and intratesticular levels of 17α-hydroxyprogesterone as well as end product testosterone were markedly elevated. Dynamic studies revealed that 17α-hydroxyprogesterone produced from pregnenolone was partly metabolized to C 19 -steroids but almost no 17α-hydroxyprogesterone produced from progesterone was utilized by C 17–20 lyase. Androstenedione levels increased in serum after both treatments and were elevated in testis tissue after hCG treatment. Androstenedione accumulated in vitro during incubation of untreated and hCG-treated testes with [ 3 H]pregnenolone and [ 14 C]progesterone. The major portion of the accumulated androstenedione was produced from pregnenolone through dehydroepiandrosterone rather than through 17α-hydroxyprogesterone, indicating differential availability of androstenedione to 17β-hydroxy steroid oxidoreductase according to its origin. The 3 H/ 14 C ratio in product androstenedione was much greater than the ratio in product testosterone in both untreated and hCG-treated testis; in testes of animals treated with hCG together with hMG, the ratios in both products were closely linked. Among the enzymes examined, 17α-hydroxylase and C17–20 lyase activities for 5-ene-C 21 -steroids were increased and 17β-hydroxysteroid oxidoreductase activity were decreased by gonadotropin treatment. Our findings confirm the phenomenon of unequal substrate availability to enzymes depending upon the provenance of the substrate and demonstrate that gonadotropin(s) change substrate availability as do direct changes in enzyme activities. The unequal substrate availability validates the assumption, previously proposed by others, that microsome enzymes have an organized arrangement as enzyme complexes." @default.
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• W2086267846 date "1984-07-01" @default.
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• W2086267846 title "Steroidogenesis in the monkey testis: Relationship of enzyme organization to endogenous steroids, steroidogenesis and gonadotropin treatment" @default.
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• W2086267846 doi "https://doi.org/10.1016/0022-4731(84)90059-1" @default.
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