FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086280801> ?p ?o ?g. }

• W2086280801 endingPage "342" @default.
• W2086280801 startingPage "333" @default.
• W2086280801 abstract "Bone morphogenetic proteins (BMPs) have unexpectedly diverse activities establishing different aspects of dorsal neural circuitry in the developing spinal cord. Our recent studies have shown that, in addition to spatially orienting dorsal commissural (dI1) axons, BMPs supply ‘temporal’ information to commissural axons to specify their rate of growth. This information ensures that commissural axons reach subsequent signals at particular times during development. However, it remains unresolved how commissural neurons specifically decode this activity of BMPs to result in their extending axons at a specific speed through the dorsal spinal cord. We have addressed this question by examining whether either of the type I BMP receptors (Bmpr), BmprIa and BmprIb, have a role controlling the rate of commissural axon growth. BmprIa and BmprIb exhibit a common function specifying the identity of dorsal cell fate in the spinal cord, whereas BmprIb alone mediates the ability of BMPs to orient axons. Here, we show that BmprIb, and not BmprIa, is additionally required to control the rate of commissural axon extension. We have also determined the intracellular effector by which BmprIb regulates commissural axon growth. We show that BmprIb has a novel role modulating the activity of the actin-severing protein cofilin. These studies reveal the mechanistic differences used by distinct components of the canonical Bmpr complex to mediate the diverse activities of the BMPs." @default.
• W2086280801 created "2016-06-24" @default.
• W2086280801 creator A5026113885 @default.
• W2086280801 creator A5054127025 @default.
• W2086280801 creator A5061144128 @default.
• W2086280801 creator A5082785018 @default.
• W2086280801 date "2013-01-15" @default.
• W2086280801 modified "2023-09-23" @default.
• W2086280801 title "Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity" @default.
• W2086280801 cites W1484094963 @default.
• W2086280801 cites W1663371441 @default.
• W2086280801 cites W1826524642 @default.
• W2086280801 cites W1837022361 @default.
• W2086280801 cites W1898205487 @default.
• W2086280801 cites W1922697055 @default.
• W2086280801 cites W1964320420 @default.
• W2086280801 cites W1990251002 @default.
• W2086280801 cites W1991993274 @default.
• W2086280801 cites W1993000387 @default.
• W2086280801 cites W1998354909 @default.
• W2086280801 cites W2005706097 @default.
• W2086280801 cites W2008333059 @default.
• W2086280801 cites W2009828482 @default.
• W2086280801 cites W2032700434 @default.
• W2086280801 cites W2033712349 @default.
• W2086280801 cites W2040078621 @default.
• W2086280801 cites W2041860435 @default.
• W2086280801 cites W2051465511 @default.
• W2086280801 cites W2065985948 @default.
• W2086280801 cites W2074273840 @default.
• W2086280801 cites W2076450755 @default.
• W2086280801 cites W2082807347 @default.
• W2086280801 cites W2092541964 @default.
• W2086280801 cites W2097458810 @default.
• W2086280801 cites W2103407592 @default.
• W2086280801 cites W2109627278 @default.
• W2086280801 cites W2128650008 @default.
• W2086280801 cites W2133030978 @default.
• W2086280801 cites W2136602932 @default.
• W2086280801 cites W2141393682 @default.
• W2086280801 cites W2142951125 @default.
• W2086280801 cites W2160834780 @default.
• W2086280801 cites W2161219665 @default.
• W2086280801 cites W2162340015 @default.
• W2086280801 cites W2163709364 @default.
• W2086280801 cites W2165695219 @default.
• W2086280801 cites W2168419545 @default.
• W2086280801 cites W2189377819 @default.
• W2086280801 cites W3022034790 @default.
• W2086280801 doi "https://doi.org/10.1242/dev.089524" @default.
• W2086280801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3597210" @default.
• W2086280801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23250207" @default.
• W2086280801 hasPublicationYear "2013" @default.
• W2086280801 type Work @default.
• W2086280801 sameAs 2086280801 @default.
• W2086280801 citedByCount "23" @default.
• W2086280801 countsByYear W20862808012013 @default.
• W2086280801 countsByYear W20862808012015 @default.
• W2086280801 countsByYear W20862808012016 @default.
• W2086280801 countsByYear W20862808012017 @default.
• W2086280801 countsByYear W20862808012018 @default.
• W2086280801 countsByYear W20862808012019 @default.
• W2086280801 countsByYear W20862808012020 @default.
• W2086280801 countsByYear W20862808012021 @default.
• W2086280801 countsByYear W20862808012022 @default.
• W2086280801 crossrefType "journal-article" @default.
• W2086280801 hasAuthorship W2086280801A5026113885 @default.
• W2086280801 hasAuthorship W2086280801A5054127025 @default.
• W2086280801 hasAuthorship W2086280801A5061144128 @default.
• W2086280801 hasAuthorship W2086280801A5082785018 @default.
• W2086280801 hasBestOaLocation W20862808011 @default.
• W2086280801 hasConcept C100207259 @default.
• W2086280801 hasConcept C104317684 @default.
• W2086280801 hasConcept C105702510 @default.
• W2086280801 hasConcept C142669718 @default.
• W2086280801 hasConcept C1491633281 @default.
• W2086280801 hasConcept C169760540 @default.
• W2086280801 hasConcept C2776601116 @default.
• W2086280801 hasConcept C2779530196 @default.
• W2086280801 hasConcept C2780775167 @default.
• W2086280801 hasConcept C2993400109 @default.
• W2086280801 hasConcept C31507581 @default.
• W2086280801 hasConcept C54355233 @default.
• W2086280801 hasConcept C69125201 @default.
• W2086280801 hasConcept C86803240 @default.
• W2086280801 hasConceptScore W2086280801C100207259 @default.
• W2086280801 hasConceptScore W2086280801C104317684 @default.
• W2086280801 hasConceptScore W2086280801C105702510 @default.
• W2086280801 hasConceptScore W2086280801C142669718 @default.
• W2086280801 hasConceptScore W2086280801C1491633281 @default.
• W2086280801 hasConceptScore W2086280801C169760540 @default.
• W2086280801 hasConceptScore W2086280801C2776601116 @default.
• W2086280801 hasConceptScore W2086280801C2779530196 @default.
• W2086280801 hasConceptScore W2086280801C2780775167 @default.
• W2086280801 hasConceptScore W2086280801C2993400109 @default.
• W2086280801 hasConceptScore W2086280801C31507581 @default.
• W2086280801 hasConceptScore W2086280801C54355233 @default.
• W2086280801 hasConceptScore W2086280801C69125201 @default.

• next