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- W2086284182 abstract "The use of carbohydrate-based wound dressings including cotton, xerogels, charcoal cloth, alginates, and hydrogels, for chronic wounds have afforded properties such as absorbency, ease of application and removal, bacterial protection, fluid balance, occlusion, and elasticity. An additional consideration is the use of the dressing to regulate proteolysis in the non-healing wound. Elastase is a serine protease that has been associated with a variety of inflammatory diseases, and recently has been implicated as a destructive protease that impedes wound healing. The presence of elevated levels of elastase in non-healing wounds has been associated with the degradation of important growth factors and fibronectin necessary for wound healing. Here we consider the design, preparation, and assessment of carbohydrate-based wound dressings that either release protease inhibitors or act as sequestering agents to bind proteases such as elastase and thus reduce their high levels in the chronic wound. Carbohydrates ranging from small monosaccahrides up to large polysaccharides are crosslinked onto cotton wound dressings. The resulting carbohydrate conjugates of cotton cellulose possess unique properties advantageous for chronic wound treatment ranging from gelation and elasticity to elastase-sequestering propertiesType in text here making sure it is in a single column format." @default.
- W2086284182 created "2016-06-24" @default.
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- W2086284182 date "2004-03-01" @default.
- W2086284182 modified "2023-09-25" @default.
- W2086284182 title "115 Carbohydrate?based Wound Dressings with Elastase?lowering Activity" @default.
- W2086284182 doi "https://doi.org/10.1111/j.1067-1927.2004.0abstractdi.x" @default.
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