FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086295818> ?p ?o ?g. }

• W2086295818 endingPage "143" @default.
• W2086295818 startingPage "133" @default.
• W2086295818 abstract "1 In native cardiac myocytes, there is a time dependence to the G protein-gated inwardly rectifying K+ (KG) channel current during voltage steps that accelerates as the concentration of acetylcholine is increased. This phenomenon has been called ‘relaxation’ and is not reproduced in the reconstituted Kir3.1/Kir3.4 channel in Xenopus oocytes. We have shown that RGS4, a regulator of G protein signalling, restores relaxation to the reconstituted Kir3.1/Kir3.4 channel. In this study, we examined the mechanism of this phenomenon by expressing various combinations of membrane receptors, G proteins, Kir3.0 subunits and mutants of RGS4 in Xenopus oocytes. 2 RGS4 restored relaxation to KG channels activated by the pertussis toxin (PTX)-sensitive G protein-coupled m2-muscarinic receptor but not to those activated by the Gs protein-coupled β2-adrenergic receptor. 3 RGS4 induced relaxation not only in heteromeric KG channels composed of Kir3.1 and Kir3.4 but also in homomeric assemblies of either an active mutant of Kir3.1 (Kir3.1/F137S) or an isoform of Kir3.2 (Kir3.2d). 4 Truncation mutants of RGS4 showed that the RGS domain itself was essential to reproduce the effect of wild-type RGS4 on the KG channel. 5 The mutation of residues in the RGS domain which interact with the α subunit of the G protein (Gα) impaired the effect of RGS4. 6 This study therefore shows that interaction between the RGS domain and PTX-sensitive Gα subunits mediates the effect of RGS4 on the agonist concentration-dependent relaxation of KG channels." @default.
• W2086295818 created "2016-06-24" @default.
• W2086295818 creator A5039772145 @default.
• W2086295818 creator A5050597064 @default.
• W2086295818 creator A5058118162 @default.
• W2086295818 creator A5060065454 @default.
• W2086295818 creator A5064280359 @default.
• W2086295818 creator A5084693611 @default.
• W2086295818 creator A5086915032 @default.
• W2086295818 date "2001-08-01" @default.
• W2086295818 modified "2023-10-18" @default.
• W2086295818 title "Interaction between the RGS domain of RGS4 with G protein α subunits mediates the voltage‐dependent relaxation of the G protein‐gated potassium channel" @default.
• W2086295818 cites W1565088438 @default.
• W2086295818 cites W1965307343 @default.
• W2086295818 cites W1968137432 @default.
• W2086295818 cites W1969018357 @default.
• W2086295818 cites W1978793024 @default.
• W2086295818 cites W1985420287 @default.
• W2086295818 cites W1986684258 @default.
• W2086295818 cites W1987475842 @default.
• W2086295818 cites W1989920655 @default.
• W2086295818 cites W1991756459 @default.
• W2086295818 cites W1996501707 @default.
• W2086295818 cites W2019273349 @default.
• W2086295818 cites W2023009549 @default.
• W2086295818 cites W2032651722 @default.
• W2086295818 cites W2042030773 @default.
• W2086295818 cites W2053217010 @default.
• W2086295818 cites W2058606373 @default.
• W2086295818 cites W2061858869 @default.
• W2086295818 cites W2064096152 @default.
• W2086295818 cites W2067854932 @default.
• W2086295818 cites W2071242185 @default.
• W2086295818 cites W2076753837 @default.
• W2086295818 cites W2086134394 @default.
• W2086295818 cites W2087139802 @default.
• W2086295818 cites W2092975281 @default.
• W2086295818 cites W2101521576 @default.
• W2086295818 cites W2116905625 @default.
• W2086295818 cites W2117918340 @default.
• W2086295818 cites W2119663191 @default.
• W2086295818 cites W2133453479 @default.
• W2086295818 doi "https://doi.org/10.1111/j.1469-7793.2001.t01-1-00133.x" @default.
• W2086295818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2278761" @default.
• W2086295818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11507164" @default.
• W2086295818 hasPublicationYear "2001" @default.
• W2086295818 type Work @default.
• W2086295818 sameAs 2086295818 @default.
• W2086295818 citedByCount "38" @default.
• W2086295818 countsByYear W20862958182012 @default.
• W2086295818 countsByYear W20862958182013 @default.
• W2086295818 countsByYear W20862958182014 @default.
• W2086295818 countsByYear W20862958182016 @default.
• W2086295818 countsByYear W20862958182017 @default.
• W2086295818 countsByYear W20862958182019 @default.
• W2086295818 countsByYear W20862958182021 @default.
• W2086295818 countsByYear W20862958182022 @default.
• W2086295818 crossrefType "journal-article" @default.
• W2086295818 hasAuthorship W2086295818A5039772145 @default.
• W2086295818 hasAuthorship W2086295818A5050597064 @default.
• W2086295818 hasAuthorship W2086295818A5058118162 @default.
• W2086295818 hasAuthorship W2086295818A5060065454 @default.
• W2086295818 hasAuthorship W2086295818A5064280359 @default.
• W2086295818 hasAuthorship W2086295818A5084693611 @default.
• W2086295818 hasAuthorship W2086295818A5086915032 @default.
• W2086295818 hasBestOaLocation W20862958182 @default.
• W2086295818 hasConcept C104292427 @default.
• W2086295818 hasConcept C104317684 @default.
• W2086295818 hasConcept C12554922 @default.
• W2086295818 hasConcept C153911025 @default.
• W2086295818 hasConcept C163181125 @default.
• W2086295818 hasConcept C185592680 @default.
• W2086295818 hasConcept C2777993845 @default.
• W2086295818 hasConcept C2779535977 @default.
• W2086295818 hasConcept C55493867 @default.
• W2086295818 hasConcept C62478195 @default.
• W2086295818 hasConcept C80631254 @default.
• W2086295818 hasConcept C83743174 @default.
• W2086295818 hasConcept C86803240 @default.
• W2086295818 hasConcept C95444343 @default.
• W2086295818 hasConceptScore W2086295818C104292427 @default.
• W2086295818 hasConceptScore W2086295818C104317684 @default.
• W2086295818 hasConceptScore W2086295818C12554922 @default.
• W2086295818 hasConceptScore W2086295818C153911025 @default.
• W2086295818 hasConceptScore W2086295818C163181125 @default.
• W2086295818 hasConceptScore W2086295818C185592680 @default.
• W2086295818 hasConceptScore W2086295818C2777993845 @default.
• W2086295818 hasConceptScore W2086295818C2779535977 @default.
• W2086295818 hasConceptScore W2086295818C55493867 @default.
• W2086295818 hasConceptScore W2086295818C62478195 @default.
• W2086295818 hasConceptScore W2086295818C80631254 @default.
• W2086295818 hasConceptScore W2086295818C83743174 @default.
• W2086295818 hasConceptScore W2086295818C86803240 @default.
• W2086295818 hasConceptScore W2086295818C95444343 @default.
• W2086295818 hasIssue "1" @default.
• W2086295818 hasLocation W20862958181 @default.
• W2086295818 hasLocation W20862958182 @default.
• W2086295818 hasLocation W20862958183 @default.

• next