Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086312448> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2086312448 abstract "The biodisposition of [3H]diisopropylfluorophosphate (DFP) and its metabolites was studied in mice after inhalation administration. In addition, the time course of DFP-induced cholinesterase inhibition in selected tissues, hypothermia, and motor coordination were studied to determine a possible correlation with [3H]DFP, or its metabolites. The time course of tissue concentrations of [3H]DFP showed that [3H]DFP rapidly penetrated all tissues and was quickly hydrolyzed to [3H]diisopropylphosphoric acid (free [3H]DIP) or was covalently bound to tissue (bound [3H]DIP). By 1 hr, the greater portion of the radioactivity was in the form of bound [3H]DIP. Cholinesterase inhibition in brain, lung, diaphragm, and plasma was temporally related to concentrations of bound [3H]DIP between 5 min and 1 day, except at early time points for the lung. Motor incoordination (rotarod test) produced by DFP exposure had a rapid onset, with complete recovery by 10 hr. DFP-induced hypothermia (rectal temperature) had a very similar time-course profile to that of motor incoordination. The time course of hypothermia and motor incoordination was correlated with neither free [3H]DFP nor bound [3H]DIP concentrations in the brain, nor with cholinesterase inhibition in brain. These findings suggest that non-cholinesterase bound [3H]DIP may contribute to the depression of these centrally mediated effects." @default.
- W2086312448 created "2016-06-24" @default.
- W2086312448 creator A5036560595 @default.
- W2086312448 creator A5036738725 @default.
- W2086312448 creator A5075600676 @default.
- W2086312448 date "1985-07-01" @default.
- W2086312448 modified "2023-09-24" @default.
- W2086312448 title "Relationship between the pharmacological effects and the biodisposition of [3H]diisopropylfluorophosphate in mice after inhalation" @default.
- W2086312448 cites W14117941 @default.
- W2086312448 cites W1985138349 @default.
- W2086312448 cites W1988665029 @default.
- W2086312448 cites W2002525162 @default.
- W2086312448 cites W2015113887 @default.
- W2086312448 cites W2019915008 @default.
- W2086312448 cites W2020447594 @default.
- W2086312448 cites W2025768273 @default.
- W2086312448 cites W2036399649 @default.
- W2086312448 cites W2039169148 @default.
- W2086312448 cites W2065190860 @default.
- W2086312448 cites W2066154139 @default.
- W2086312448 cites W2070751462 @default.
- W2086312448 cites W2074016188 @default.
- W2086312448 cites W2078133823 @default.
- W2086312448 cites W225649912 @default.
- W2086312448 cites W2397141862 @default.
- W2086312448 cites W2404529544 @default.
- W2086312448 cites W2954157421 @default.
- W2086312448 cites W2954384963 @default.
- W2086312448 cites W2955094019 @default.
- W2086312448 doi "https://doi.org/10.1016/0041-008x(85)90147-4" @default.
- W2086312448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4035691" @default.
- W2086312448 hasPublicationYear "1985" @default.
- W2086312448 type Work @default.
- W2086312448 sameAs 2086312448 @default.
- W2086312448 citedByCount "11" @default.
- W2086312448 countsByYear W20863124482015 @default.
- W2086312448 countsByYear W20863124482020 @default.
- W2086312448 crossrefType "journal-article" @default.
- W2086312448 hasAuthorship W2086312448A5036560595 @default.
- W2086312448 hasAuthorship W2086312448A5036738725 @default.
- W2086312448 hasAuthorship W2086312448A5075600676 @default.
- W2086312448 hasConcept C121332964 @default.
- W2086312448 hasConcept C126322002 @default.
- W2086312448 hasConcept C134018914 @default.
- W2086312448 hasConcept C157138929 @default.
- W2086312448 hasConcept C164292776 @default.
- W2086312448 hasConcept C181199279 @default.
- W2086312448 hasConcept C185592680 @default.
- W2086312448 hasConcept C24890656 @default.
- W2086312448 hasConcept C2776954882 @default.
- W2086312448 hasConcept C2777390192 @default.
- W2086312448 hasConcept C2778816929 @default.
- W2086312448 hasConcept C2779059548 @default.
- W2086312448 hasConcept C31896038 @default.
- W2086312448 hasConcept C42219234 @default.
- W2086312448 hasConcept C55493867 @default.
- W2086312448 hasConcept C71924100 @default.
- W2086312448 hasConcept C98274493 @default.
- W2086312448 hasConceptScore W2086312448C121332964 @default.
- W2086312448 hasConceptScore W2086312448C126322002 @default.
- W2086312448 hasConceptScore W2086312448C134018914 @default.
- W2086312448 hasConceptScore W2086312448C157138929 @default.
- W2086312448 hasConceptScore W2086312448C164292776 @default.
- W2086312448 hasConceptScore W2086312448C181199279 @default.
- W2086312448 hasConceptScore W2086312448C185592680 @default.
- W2086312448 hasConceptScore W2086312448C24890656 @default.
- W2086312448 hasConceptScore W2086312448C2776954882 @default.
- W2086312448 hasConceptScore W2086312448C2777390192 @default.
- W2086312448 hasConceptScore W2086312448C2778816929 @default.
- W2086312448 hasConceptScore W2086312448C2779059548 @default.
- W2086312448 hasConceptScore W2086312448C31896038 @default.
- W2086312448 hasConceptScore W2086312448C42219234 @default.
- W2086312448 hasConceptScore W2086312448C55493867 @default.
- W2086312448 hasConceptScore W2086312448C71924100 @default.
- W2086312448 hasConceptScore W2086312448C98274493 @default.
- W2086312448 hasLocation W20863124481 @default.
- W2086312448 hasLocation W20863124482 @default.
- W2086312448 hasOpenAccess W2086312448 @default.
- W2086312448 hasPrimaryLocation W20863124481 @default.
- W2086312448 hasRelatedWork W2015065728 @default.
- W2086312448 hasRelatedWork W2072812615 @default.
- W2086312448 hasRelatedWork W2083173494 @default.
- W2086312448 hasRelatedWork W2086312448 @default.
- W2086312448 hasRelatedWork W2105382709 @default.
- W2086312448 hasRelatedWork W2122082133 @default.
- W2086312448 hasRelatedWork W2400401827 @default.
- W2086312448 hasRelatedWork W2411626180 @default.
- W2086312448 hasRelatedWork W2438263105 @default.
- W2086312448 hasRelatedWork W169864295 @default.
- W2086312448 isParatext "false" @default.
- W2086312448 isRetracted "false" @default.
- W2086312448 magId "2086312448" @default.
- W2086312448 workType "article" @default.