Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086320468> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2086320468 endingPage "506" @default.
- W2086320468 startingPage "497" @default.
- W2086320468 abstract "Background: Ranitidine bismuth citrate (GR122311X) is a new drug which offers potential benefits in healing duodenal ulcers and prevention of relapse. Methods: This randomized, multi-centre double-blind study of 1620 patients compared the effect of 4 weeks of treatment with GR122311X 200 mg b.d. (n= 401), 400 mg b.d. (n= 404) or 800 mg b.d. (n= 404) or ranitidine hydrochloride 150 mg b.d. (n= 411) on the rates of duodenal ulcer healing and of overall success (ulcers healed and remaining ulcer free in the 24-week follow-up phase). Results: All four treatments were equally effective at ulcer healing (79%, 85%, 84% and 81% of patients, respectively). GR122311X 400 mg b.d. (38%) and 800 mg b.d. (37%) were significantly more effective than ranitidine hydrochloride 150 mg b.d. (32%) with respect to overall success (P = 0.050 and P = 0.030, respectively) but there was no difference with GR122311X 200 mg b.d. (31%). GR122311X caused effective, dose-related suppression of H. pylori (47%, 61% and 74%); H. pylori eradication rates were 18%, 21% and 22%. GR122311X was safe and well tolerated, with an adverse event profile similar to that of ranitidine hydrochloride 150 mg b.d. Median week 4 trough plasma bismuth levels were 1.3 ng/mL, 2.3 ng/mL and 3.3 ng/mL with GR122311X 200 mg b.d., 400 mg b.d. and 800 mg b.d. respectively. No individual plasma bismuth concentrations were of clinical concern. Conclusions: GR122311X is a safe and effective ulcer healing drug, and provides a platform on which anti-H. pylori therapy can be based." @default.
- W2086320468 created "2016-06-24" @default.
- W2086320468 creator A5007001177 @default.
- W2086320468 creator A5008565470 @default.
- W2086320468 creator A5014187734 @default.
- W2086320468 creator A5014454440 @default.
- W2086320468 creator A5016194904 @default.
- W2086320468 creator A5027642904 @default.
- W2086320468 creator A5029791109 @default.
- W2086320468 creator A5039555846 @default.
- W2086320468 creator A5044710658 @default.
- W2086320468 creator A5054351899 @default.
- W2086320468 creator A5073498218 @default.
- W2086320468 creator A5084323253 @default.
- W2086320468 date "2007-03-31" @default.
- W2086320468 modified "2023-10-08" @default.
- W2086320468 title "GR122311X (ranitidine bismuth citrate), a new drug for the treatment of duodenal ulcer" @default.
- W2086320468 cites W1983347280 @default.
- W2086320468 cites W1990362468 @default.
- W2086320468 cites W2020526148 @default.
- W2086320468 cites W2034817878 @default.
- W2086320468 cites W2044439931 @default.
- W2086320468 cites W2050115769 @default.
- W2086320468 cites W3190641531 @default.
- W2086320468 doi "https://doi.org/10.1111/j.1365-2036.1995.tb00412.x" @default.
- W2086320468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8580269" @default.
- W2086320468 hasPublicationYear "2007" @default.
- W2086320468 type Work @default.
- W2086320468 sameAs 2086320468 @default.
- W2086320468 citedByCount "15" @default.
- W2086320468 countsByYear W20863204682023 @default.
- W2086320468 crossrefType "journal-article" @default.
- W2086320468 hasAuthorship W2086320468A5007001177 @default.
- W2086320468 hasAuthorship W2086320468A5008565470 @default.
- W2086320468 hasAuthorship W2086320468A5014187734 @default.
- W2086320468 hasAuthorship W2086320468A5014454440 @default.
- W2086320468 hasAuthorship W2086320468A5016194904 @default.
- W2086320468 hasAuthorship W2086320468A5027642904 @default.
- W2086320468 hasAuthorship W2086320468A5029791109 @default.
- W2086320468 hasAuthorship W2086320468A5039555846 @default.
- W2086320468 hasAuthorship W2086320468A5044710658 @default.
- W2086320468 hasAuthorship W2086320468A5054351899 @default.
- W2086320468 hasAuthorship W2086320468A5073498218 @default.
- W2086320468 hasAuthorship W2086320468A5084323253 @default.
- W2086320468 hasConcept C126322002 @default.
- W2086320468 hasConcept C197934379 @default.
- W2086320468 hasConcept C2777445857 @default.
- W2086320468 hasConcept C2780035454 @default.
- W2086320468 hasConcept C2910259375 @default.
- W2086320468 hasConcept C2993747882 @default.
- W2086320468 hasConcept C71924100 @default.
- W2086320468 hasConcept C90924648 @default.
- W2086320468 hasConcept C98274493 @default.
- W2086320468 hasConceptScore W2086320468C126322002 @default.
- W2086320468 hasConceptScore W2086320468C197934379 @default.
- W2086320468 hasConceptScore W2086320468C2777445857 @default.
- W2086320468 hasConceptScore W2086320468C2780035454 @default.
- W2086320468 hasConceptScore W2086320468C2910259375 @default.
- W2086320468 hasConceptScore W2086320468C2993747882 @default.
- W2086320468 hasConceptScore W2086320468C71924100 @default.
- W2086320468 hasConceptScore W2086320468C90924648 @default.
- W2086320468 hasConceptScore W2086320468C98274493 @default.
- W2086320468 hasIssue "5" @default.
- W2086320468 hasLocation W20863204681 @default.
- W2086320468 hasLocation W20863204682 @default.
- W2086320468 hasOpenAccess W2086320468 @default.
- W2086320468 hasPrimaryLocation W20863204681 @default.
- W2086320468 hasRelatedWork W1999603996 @default.
- W2086320468 hasRelatedWork W2073031732 @default.
- W2086320468 hasRelatedWork W2074346199 @default.
- W2086320468 hasRelatedWork W2086320468 @default.
- W2086320468 hasRelatedWork W2314810050 @default.
- W2086320468 hasRelatedWork W2384380501 @default.
- W2086320468 hasRelatedWork W2405144512 @default.
- W2086320468 hasRelatedWork W2467112689 @default.
- W2086320468 hasRelatedWork W3031757551 @default.
- W2086320468 hasRelatedWork W4246715436 @default.
- W2086320468 hasVolume "9" @default.
- W2086320468 isParatext "false" @default.
- W2086320468 isRetracted "false" @default.
- W2086320468 magId "2086320468" @default.
- W2086320468 workType "article" @default.