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- W2086329101 endingPage "30" @default.
- W2086329101 startingPage "21" @default.
- W2086329101 abstract "Cellular homeostasis depends upon the strict regulation of responses to external stimuli, such as signalling cascades triggered by nutrients and growth factors, and upon cellular metabolism. One of the major molecules coordinating complex signalling pathways is protein kinase B (PKB), a serine/threonine kinase also known as Akt. The number of substrates known to be phosphorylated by PKB and its interacting partners, as well as our broad understanding of how PKB is implicated in responses to growth factors, metabolic pathways, proliferation, and cell death via apoptosis is constantly increasing. Activated by the insulin/growth factor-phosphatidylinositol 3-kinase (PI3K) cascade, PKB triggers events that promote cell survival and prevent apoptosis. It is also now widely accepted that mitochondria are not just suppliers of ATP, but that they participate in regulatory and signalling events, responding to multiple physiological inputs and genetic stresses, and regulate both cell proliferation and death. Thus, mitochondria are recognized as important players in apoptotic events and it is logical to predict some form of interplay with PKB. In this review, we will summarize mechanisms by which PKB mediates its anti-apoptotic activities in cells and survey recent developments in understanding mitochondrial dynamics and their role during apoptosis." @default.
- W2086329101 created "2016-06-24" @default.
- W2086329101 creator A5019929980 @default.
- W2086329101 creator A5021249422 @default.
- W2086329101 creator A5027097638 @default.
- W2086329101 creator A5067998513 @default.
- W2086329101 date "2008-01-01" @default.
- W2086329101 modified "2023-10-06" @default.
- W2086329101 title "PKB and the mitochondria: AKTing on apoptosis" @default.
- W2086329101 cites W1480948328 @default.
- W2086329101 cites W1496902741 @default.
- W2086329101 cites W1506642042 @default.
- W2086329101 cites W1591022300 @default.
- W2086329101 cites W1593734817 @default.
- W2086329101 cites W1598719623 @default.
- W2086329101 cites W1607777232 @default.
- W2086329101 cites W1617532721 @default.
- W2086329101 cites W1625966995 @default.
- W2086329101 cites W1845459216 @default.
- W2086329101 cites W1904882776 @default.
- W2086329101 cites W1917984366 @default.
- W2086329101 cites W1965705993 @default.
- W2086329101 cites W1966798559 @default.
- W2086329101 cites W1966928113 @default.
- W2086329101 cites W1968837506 @default.
- W2086329101 cites W1970248089 @default.
- W2086329101 cites W1970514669 @default.
- W2086329101 cites W1972546884 @default.
- W2086329101 cites W1974140472 @default.
- W2086329101 cites W1975290731 @default.
- W2086329101 cites W1975731421 @default.
- W2086329101 cites W1976160299 @default.
- W2086329101 cites W1976417809 @default.
- W2086329101 cites W1978423374 @default.
- W2086329101 cites W1979489548 @default.
- W2086329101 cites W1979909416 @default.
- W2086329101 cites W1984621921 @default.
- W2086329101 cites W1986854615 @default.
- W2086329101 cites W1993904017 @default.
- W2086329101 cites W1995463051 @default.
- W2086329101 cites W1995828011 @default.
- W2086329101 cites W1996234796 @default.
- W2086329101 cites W1996979039 @default.
- W2086329101 cites W1997038002 @default.
- W2086329101 cites W1997219075 @default.
- W2086329101 cites W1997879915 @default.
- W2086329101 cites W2002555521 @default.
- W2086329101 cites W2003907026 @default.
- W2086329101 cites W2005263183 @default.
- W2086329101 cites W2008257691 @default.
- W2086329101 cites W2008987764 @default.
- W2086329101 cites W2009183764 @default.
- W2086329101 cites W2011818472 @default.
- W2086329101 cites W2011912935 @default.
- W2086329101 cites W2013091489 @default.
- W2086329101 cites W2013685285 @default.
- W2086329101 cites W2015432978 @default.
- W2086329101 cites W2015543753 @default.
- W2086329101 cites W2015753524 @default.
- W2086329101 cites W2017882961 @default.
- W2086329101 cites W2018136707 @default.
- W2086329101 cites W2019047215 @default.
- W2086329101 cites W2019872821 @default.
- W2086329101 cites W2023726011 @default.
- W2086329101 cites W2024306318 @default.
- W2086329101 cites W2026555011 @default.
- W2086329101 cites W2029370718 @default.
- W2086329101 cites W2029502542 @default.
- W2086329101 cites W2030573603 @default.
- W2086329101 cites W2032531389 @default.
- W2086329101 cites W2033771437 @default.
- W2086329101 cites W2033801757 @default.
- W2086329101 cites W2035008060 @default.
- W2086329101 cites W2035531438 @default.
- W2086329101 cites W2036371153 @default.
- W2086329101 cites W2037839882 @default.
- W2086329101 cites W2039355845 @default.
- W2086329101 cites W2040143421 @default.
- W2086329101 cites W2042409437 @default.
- W2086329101 cites W2042790425 @default.
- W2086329101 cites W2046603670 @default.
- W2086329101 cites W2049187899 @default.
- W2086329101 cites W2052853635 @default.
- W2086329101 cites W2053265248 @default.
- W2086329101 cites W2055094310 @default.
- W2086329101 cites W2058138221 @default.
- W2086329101 cites W2059221693 @default.
- W2086329101 cites W2068912983 @default.
- W2086329101 cites W2069206405 @default.
- W2086329101 cites W2069508460 @default.
- W2086329101 cites W2070732456 @default.
- W2086329101 cites W2070764343 @default.
- W2086329101 cites W2071475119 @default.
- W2086329101 cites W2074800090 @default.
- W2086329101 cites W2077173862 @default.
- W2086329101 cites W2077672936 @default.
- W2086329101 cites W2081826708 @default.
- W2086329101 cites W2082335615 @default.