FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086357106> ?p ?o ?g. }

• W2086357106 endingPage "572" @default.
• W2086357106 startingPage "567" @default.
• W2086357106 abstract "1. Perivascular nerves of the sheep middle cerebral artery show immunoreactivity for both vasoactive intestinal polypeptide (VIP) and calcitonin gene-related peptide (CGRP). 2. Rings of endothelium-denuded sheep middle cerebral artery precontracted with 5-hydroxytryptamine were relaxed by CGRP (maximum relaxation = 87.8 +/- 8.1%, pD2 = 7.81 +/- 0.12, n = 12) and by VIP (maximum relaxation = 55.1 +/- 4.1%, pD2 = 7.65 +/- 0.04, n = 18). Rings of endothelium-denuded cat middle cerebral artery precontracted with U46619 were also relaxed by vasoactive intestinal polypeptide (maximum relaxation = 53.1 +/- 6.1%, pD2 = 7.82 +/- 0.11, n = 6). 3. Haemolysate (1 microliters ml-1) inhibited VIP-induced relaxation in endothelium-denuded sheep and cat middle cerebral artery (n = 6) but had no effect on the CGRP-induced relaxation of the sheep middle cerebral artery (n = 6). 4. The relaxant response to VIP in endothelium-denuded sheep middle cerebral artery was inhibited by methylene blue (10 microM) and augmented by either M&B 22948 (10 microM) or superoxide dismutase (150 units ml-1). Indomethacin (1 microM) had no effect. 5. The addition of L-NG-monomethyl arginine (100 microM) inhibited both neurogenic and VIP-induced relaxation of endothelium-denuded sheep MCA by 56 +/- 6% and 60 +/- 6% (n = 5) respectively. The CGRP-induced relaxation was unaffected. 6. It is concluded that neurally mediated vasodilatation in the sheep middle cerebral artery is mediated largely by VIP through a direct action on smooth muscle through a cyclic-GMP-mediated mechanism that appears to involve synthesis of nitric oxide from L-arginine. Vasodilatation by CGRP, which is also contained in perivascular nerves, does not utilize this pathway." @default.
• W2086357106 created "2016-06-24" @default.
• W2086357106 creator A5007201833 @default.
• W2086357106 creator A5041298768 @default.
• W2086357106 creator A5055956601 @default.
• W2086357106 creator A5058369958 @default.
• W2086357106 creator A5074904784 @default.
• W2086357106 date "1991-03-01" @default.
• W2086357106 modified "2023-10-14" @default.
• W2086357106 title "Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by l-NG-monomethyl arginine in endothelium-denuded vessels" @default.
• W2086357106 cites W1883766901 @default.
• W2086357106 cites W1965248215 @default.
• W2086357106 cites W1970204917 @default.
• W2086357106 cites W1976102520 @default.
• W2086357106 cites W1981046160 @default.
• W2086357106 cites W1985753711 @default.
• W2086357106 cites W1985894102 @default.
• W2086357106 cites W1989278778 @default.
• W2086357106 cites W1990845205 @default.
• W2086357106 cites W1991143553 @default.
• W2086357106 cites W1994950364 @default.
• W2086357106 cites W1996929606 @default.
• W2086357106 cites W2003207398 @default.
• W2086357106 cites W2005681084 @default.
• W2086357106 cites W2006720889 @default.
• W2086357106 cites W2014281315 @default.
• W2086357106 cites W2016204376 @default.
• W2086357106 cites W2016299086 @default.
• W2086357106 cites W2029253166 @default.
• W2086357106 cites W2039523986 @default.
• W2086357106 cites W2052166433 @default.
• W2086357106 cites W2057025197 @default.
• W2086357106 cites W2061406499 @default.
• W2086357106 cites W2063422668 @default.
• W2086357106 cites W2065948307 @default.
• W2086357106 cites W2067770662 @default.
• W2086357106 cites W2076176244 @default.
• W2086357106 cites W2080325855 @default.
• W2086357106 cites W2094101909 @default.
• W2086357106 cites W2112407697 @default.
• W2086357106 cites W2142975032 @default.
• W2086357106 cites W2165343984 @default.
• W2086357106 cites W2257066012 @default.
• W2086357106 cites W2314926292 @default.
• W2086357106 cites W2413171618 @default.
• W2086357106 doi "https://doi.org/10.1111/j.1476-5381.1991.tb12213.x" @default.
• W2086357106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917941" @default.
• W2086357106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1364820" @default.
• W2086357106 hasPublicationYear "1991" @default.
• W2086357106 type Work @default.
• W2086357106 sameAs 2086357106 @default.
• W2086357106 citedByCount "81" @default.
• W2086357106 countsByYear W20863571062013 @default.
• W2086357106 countsByYear W20863571062016 @default.
• W2086357106 countsByYear W20863571062018 @default.
• W2086357106 countsByYear W20863571062020 @default.
• W2086357106 countsByYear W20863571062021 @default.
• W2086357106 countsByYear W20863571062022 @default.
• W2086357106 crossrefType "journal-article" @default.
• W2086357106 hasAuthorship W2086357106A5007201833 @default.
• W2086357106 hasAuthorship W2086357106A5041298768 @default.
• W2086357106 hasAuthorship W2086357106A5055956601 @default.
• W2086357106 hasAuthorship W2086357106A5058369958 @default.
• W2086357106 hasAuthorship W2086357106A5074904784 @default.
• W2086357106 hasBestOaLocation W20863571061 @default.
• W2086357106 hasConcept C118303440 @default.
• W2086357106 hasConcept C120770815 @default.
• W2086357106 hasConcept C126322002 @default.
• W2086357106 hasConcept C134018914 @default.
• W2086357106 hasConcept C163170386 @default.
• W2086357106 hasConcept C170493617 @default.
• W2086357106 hasConcept C171614378 @default.
• W2086357106 hasConcept C185592680 @default.
• W2086357106 hasConcept C2775841333 @default.
• W2086357106 hasConcept C2776992346 @default.
• W2086357106 hasConcept C2777663904 @default.
• W2086357106 hasConcept C519581460 @default.
• W2086357106 hasConcept C541997718 @default.
• W2086357106 hasConcept C71924100 @default.
• W2086357106 hasConcept C8330315 @default.
• W2086357106 hasConceptScore W2086357106C118303440 @default.
• W2086357106 hasConceptScore W2086357106C120770815 @default.
• W2086357106 hasConceptScore W2086357106C126322002 @default.
• W2086357106 hasConceptScore W2086357106C134018914 @default.
• W2086357106 hasConceptScore W2086357106C163170386 @default.
• W2086357106 hasConceptScore W2086357106C170493617 @default.
• W2086357106 hasConceptScore W2086357106C171614378 @default.
• W2086357106 hasConceptScore W2086357106C185592680 @default.
• W2086357106 hasConceptScore W2086357106C2775841333 @default.
• W2086357106 hasConceptScore W2086357106C2776992346 @default.
• W2086357106 hasConceptScore W2086357106C2777663904 @default.
• W2086357106 hasConceptScore W2086357106C519581460 @default.
• W2086357106 hasConceptScore W2086357106C541997718 @default.
• W2086357106 hasConceptScore W2086357106C71924100 @default.
• W2086357106 hasConceptScore W2086357106C8330315 @default.
• W2086357106 hasIssue "3" @default.
• W2086357106 hasLocation W20863571061 @default.
• W2086357106 hasLocation W20863571062 @default.

• next